Soluble epoxide hydrolase inhibitors have been reported as antihypertensive, anti-inflammatory, antiulcer and anticancer actions protect the brain, heart kidney from damage. Exploring soluble inhibition activity of traditional medicinal plants helps to uncover new target treat various complications associated with inflammatory mediators. The present study was planned explore fifty commonly used...

Objective: The aim of this investigation was to enhance the solubility and bioavailability BCS class II poorly water-soluble drug ambrisentan by solid dispersion (SD) techniques using Gelucire 50/13 as a hydrophilic carrier. Methods: Solid prepared kneading method different dug: carrier ratios. Prepared SD characterized for solubility, content, percentage yield, in vitro dissolution, ex vivo pe...

Background/aim Endothelin causes vasoconstriction via the endothelin-A receptor (ET-A) in intrahepatic circulation cirrhosis and its increase leads to portal hypertension. The aim of study was investigate acute effect a selective ET-A antagonist patients with hypertension cirrhosis. Methods Proof-of-concept two different substudies: (a) local administration BQ 123 (b) systemic oral Ambrisentan....

Pulmonary arterial hypertension (PAH) is a deadly and underdiagnosed disease which causes right heart failure secondary to pressure overload resulting from the thickening of the pulmonary artery endothelium, associated with elevated levels of circulating endothelin-1. Sitaxentan was the fi rst endothelin antagonist with high selectivity for receptor subtype A (over subtype ET-B) to gain regulat...