نتایج جستجو برای: am251

تعداد نتایج: 328  

Journal: :Journal of neurochemistry 2006
Joseph F Cheer Kate M Wassum R Mark Wightman

Cannabinoid receptors have been implicated in the regulation of blood flow in the cerebral vasculature. Because the nucleus accumbens (NAc) shows high levels of central cannabinoid receptor 1 (CB1) expression we examined the effects of cannabinoids on the local transient alkaline shifts and increases in extracellular oxygen induced by electrical stimulation of the medial forebrain bundle (MFB) ...

Journal: :PLoS ONE 2008
Puspha Sinnayah Erin E. Jobst Joseph A. Rathner Angela D. Caldera-Siu Luciana Tonelli-Lemos Aaron J. Eusterbrock Pablo J. Enriori Emmanuel N. Pothos Kevin L. Grove Michael A. Cowley

BACKGROUND Cannabinoids, the active components of marijuana, stimulate appetite, and cannabinoid receptor-1 (CB1-R) antagonists suppress appetite and promote weight loss. Little is known about how CB1-R antagonists affect the central neurocircuitry, specifically the melanocortin system that regulates energy balance. METHODOLOGY/PRINCIPAL FINDINGS Here, we show that peripherally administered C...

2014
Yann Ravussin Cuiying Xiao Oksana Gavrilova Marc L. Reitman

Homeotherms have specific mechanisms to maintain a constant core body temperature despite changes in thermal environment, food supply, and metabolic demand. Brown adipose tissue, the principal thermogenic organ, quickly and efficiently increases heat production by dissipating the mitochondrial proton motive force. It has been suggested that activation of brown fat, via either environmental (i.e...

Journal: :Anesthesiology 2003
Aline Quartilho Heriberto P Mata Mohab M Ibrahim Todd W Vanderah Frank Porreca Alexandros Makriyannis T Philip Malan

BACKGROUND Cannabinoid receptor agonists inhibit inflammatory hyperalgesia in animal models. Nonselective cannabinoid receptor agonists also produce central nervous system (CNS) side effects. Agonists selective for CB2 cannabinoid receptors, which are not found in the CNS, do not produce the CNS effects typical of nonselective cannabinoid receptor agonists but do inhibit acute nociception. The ...

2017
Na Cui Changyan Wang Zhiming Zhao Jie Zhang Yueming Xu Yang Yang Guimin Hao

BACKGROUND/AIMS We investigated the role of the endocannabinoid system (ECS) in the endometrium of unexplained infertility (UI) patients, and effect of anandamide (AEA) on leukemia inhibitory factor (LIF). METHODS Patients were divided into UI and control groups. Endometrium samples were collected at the midluteal phase. Levels of cannabinoid type 1 (CB1), fatty acid amide hydrolase (FAAH), a...

2013
Maryam Karamikheirabad Gila Behzadi Mahdieh Faghihi Reza Raoofian Shahram Ejtemaei Mehr Wieteke Ameliek Zuure Hamid Reza Sadeghipour

OBJECTIVE Stress is known to be an inhibitor of the reproductive hypothalamic-pituitary-gonadal (HPG) axis. However, the neural and molecular connections between stress and reproduction are not yet understood. It is well established that in both humans and rodents, kisspeptin (encoded by the kiss1 gene) is a strong stimulator of the HPG axis. In the present study we hypothesized that endocannab...

Journal: :Neural plasticity 2016
Joseph Bouskila Vanessa Harrar Pasha Javadi Amy Beierschmitt Roberta Palmour Christian Casanova Jean-François Bouchard Maurice Ptito

The expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) and CB2R is exclusively found in the retinal glia (Müller cells). However, the role of these cannab...

Journal: :Frontiers in cellular neuroscience 2016
Flóra Bálint Zsolt Liposits Imre Farkas

Gonadotropin-releasing hormone (GnRH) neurons are controlled by 17β-estradiol (E2) contributing to the steroid feedback regulation of the reproductive axis. In rodents, E2 exerts a negative feedback effect upon GnRH neurons throughout the estrus-diestrus phase of the ovarian cycle. The present study was undertaken to reveal the role of estrogen receptor subtypes in the mediation of the E2 signa...

2014
Daniela Laricchiuta Alessandra Musella Silvia Rossi Diego Centonze

Rewarding effects have been related to enhanced dopamine (DA) release in corticolimbic and basal ganglia structures. The DAergic and endocannabinoid interaction in the responses to reward is described. This study investigated the link between endocannabinoid and DAergic transmission in the processes that are related to response to two types of reward, palatable food and novelty. Mice treated wi...

Journal: :The British journal of nutrition 2011
Lamiae Bakkali-Kassemi Seloua El Ouezzani Rabia Magoul Ikram Merroun Maria Lopez-Jurado Mohammed Errami

The control of appetite and satiety is extremely complex and involves a balance between neurotransmitters and neuropeptides to stimulate and/or inhibit feeding behaviour. The effect of cannabinoids on food intake is well established, but little is known about the mechanism of action underlying their activity. In the present report, the effect of pharmacological manipulation of the cannabinoid r...

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