We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD).A retrospective population-based nested case-control study. Newly diagnosed dementia patients 65 years and older and controls were sampled. A total of 8406 dementia and 16,812 control subjects were enrolled from Taiwan NHIRD during 2006 to 2010. Th...

Of 35 stool specimens isolated and examined in 293 cells, 15 isolates contained adenovirus species 40 (Ad40), and 4 of these 15 isolates also contained a nonfastidious adenovirus species (Ad1 in two cases, Ad18 or Ad31) which was selected over Ad40 during serial passage in the 293 cells. The selection of Ad1 over Ad40 was examined in detail. Restriction analysis of intracellular DNA and the rel...

Numerous basic studies have reported on the neuroprotective properties of several purine derivatives such as caffeine and uric acid (UA). Epidemiological also shown inverse association appropriate intake or serum urate levels with neurodegenerative diseases Alzheimer disease (AD) Parkinson’s (PD). The well-established mechanisms UA involve adenosine A2A receptor antagonism antioxidant activity,...

Abstrak
 Penyakit Alzheimer merupakan penyakit neurodegeneratif yang ditandai dengan memori dan penurunan fungsi kognitif. Gejala alzheimer mengacaukan, pemandangan tidak tepat, iritasi, penarikan, halusinasi. Mikrobiota usus otak (MGBA) suatu sistem komunikasi kompleks antara GIT, mikroorganime saraf pusat mentrasmisikan informasi dari ke serta digunakan untuk mengobati memperbaiki gejala...

The neurological deterioration associated with Alzheimer's disease (AD), involving accumulation of amyloid-beta peptides and neurofibrillary tangles, is associated with evident neuroinflammation. This is now seen to be a significant contributor to pathology. Recently the tenet of the privileged status of the brain, regarding microbial compromise, has been questioned, particularly in terms of ne...

Genetic studies have led to major discoveries in the pathogenesis of various neurodegenerative diseases. Ubiquitin-positive familial frontotemporal dementia was recently found to be caused by mutations in the progranulin gene (PGRN), and the major constituent of the inclusions, TDP-43, was subsequently identified. The tau gene (MAPT) causes frontotemporal dementia with parkinsonism linked to ch...

Neurological diseases such as Alzheimer, Parkinson, and ischemic stroke have increased in occurrence and become important health issues throughout the world. There is currently no effective therapeutic strategy for addressing neurological deficits after the development of these major neurological disorders. In recent years, it has become accepted that adult neural stem cells located in the subv...

Handwritten signatures are generally considered a powerful biometric traits for personal verification. Recently, handwritten signatures have been also investigated for early diagnosis of neurodegenerative diseases. This paper presents a new approach for early diagnosis of neurodegenerative diseases by the analysis of handwritten dynamic signatures. For the purpose, the sigma-lognormal model was...