Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxid...

nowadays, air pollution is one of the major problems in developed and developing countries. in recent years, effects of air pollution on neuroinflammatory diseases such as alzheimer disease and parkinson disease have been studied. researches on polluted cities citizens indicate increasing in central nervous system (cns) inflammatory factors in comparison with clean cities; also air pollution ex...

background: metal ions effect on homeostasis of alzheimer’s disease (ad) patients. the aim of this study was to assess the metal ions (iron, zinc and copper) and cbc in patients with ad in comparison with normal range. methods: the samples of study were 17 patients with ad in tehran’s aging centers in 2015, selected as an access sample. blood samples were analyzed in a pathobiology laboratory. ...

background: sporadic alzheimer’s disease (sad) is caused by genetic risk factors, aging and oxidative stresses. the herbal extract of rosa canina (r. canina), tanacetum vulgare (t. vulgare) and urtica dioica (u. dioica) has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. in this study, the neuroprotective effects of this herbal extract in the rat model of sad was i...

Alzheimer disease (AD) is a progressive neurodegenerative disorder affecting more than 37 million people worldwide and increasing in incidence based on its primary risk factor, advancing age. A growing body of knowledge regarding amyloid and tau neuropathology, genetic and environmental risk modifiers, early and atypical clinical presentations, and the use of symptom-modifying medical and psych...