نتایج جستجو برای: alps

تعداد نتایج: 5744  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
João B Oliveira Nicolas Bidère Julie E Niemela Lixin Zheng Keiko Sakai Cynthia P Nix Robert L Danner Jennifer Barb Peter J Munson Jennifer M Puck Janet Dale Stephen E Straus Thomas A Fleisher Michael J Lenardo

The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leading to Noonan, cardio-facial-cutaneous, and Costello syndrome, but activating g...

2009
Frank Paul Wilfried Haeberli

Massive glacier thinning in the Alps during the past 20 years is documented by direct mass balance measurements on nine regularly observed glaciers. How representative this limited sample of glaciers is for the entire Alps, however, remained uncertain. The near-global digital terrain model from the SRTM enables a closer analysis of this question, which is of fundamental importance to assess ove...

2011
Iwona M. Pranke Vincent Morello Joëlle Bigay Kimberley Gibson Jean-Marc Verbavatz Bruno Antonny Catherine L. Jackson

Membrane curvature sensors have diverse structures and chemistries, suggesting that they might have the intrinsic capacity to discriminate between different types of vesicles in cells. In this paper, we compare the in vitro and in vivo membrane-binding properties of two curvature sensors that form very different amphipathic helices: the amphipathic lipid-packing sensor (ALPS) motif of a Golgi v...

2015
Lukas Bickel Christopher Lüthgens Johanna Lomax Markus Fiebig

During the penultimate glaciation vast areas of the Alps were glaciated, with piedmont glaciers protruding into the foreland. In the easternmost part of the northward draining valleys of the Alps, the glaciers did not reach the foreland, but formed valley glaciers confined by the mountainous terrain. This also applies to the Ybbs valley, where samples for luminescence dating out of glaciofluvia...

Journal: :Molecular ecology 2010
Bénédicte N Poncet Doris Herrmann Felix Gugerli Pierre Taberlet Rolf Holderegger Ludovic Gielly Delphine Rioux Wilfried Thuiller Serge Aubert Stéphanie Manel

Understanding the genetic basis of adaptation in response to environmental variation is fundamental as adaptation plays a key role in the extension of ecological niches to marginal habitats and in ecological speciation. Based on the assumption that some genomic markers are correlated to environmental variables, we aimed to detect loci of ecological relevance in the alpine plant Arabis alpina L....

Journal: :Molecular phylogenetics and evolution 2010
Matthias Borer Nadir Alvarez Sven Buerki Nicolas Margraf Martine Rahier Russell E Naisbit

The genetic landscape of the European flora and fauna was shaped by the ebb and flow of populations with the shifting ice during Quaternary climate cycles. While this has been well demonstrated for lowland species, less is known about high altitude taxa. Here we analyze the phylogeography of the leaf beetle Oreina elongata from 20 populations across the Alps and Apennines. Three mitochondrial a...

2017
Xiaoxie Xu Jun Huang Mei Zhao Huanpeng Chen Jinhua Mo Xiaoqing Zhou Qiao Su Bolan Yu Zhaofeng Huang

Autoimmune lymphoproliferative syndrome (ALPS) is an incurable disease mainly caused by the defect of Fas-mediated apoptosis and characterized by nonmalignant autoimmune lymphoproliferation. Stabilized β-catenin could not only potentiate Fas-mediated T cell apoptosis via upregulating the expression of Fas on activated T cells, but also potentiate T cell apoptosis via intrinsic apoptotic pathway...

2012
Andreas Ringwald

We review searches for closed string axions and axion-like particles (ALPs) in IIB string flux compactifications. For natural values of the background fluxes and TeV scale gravitino mass, the moduli stabilisation mechanism of the LARGE Volume Scenario predicts the existence of a QCD axion candidate with intermediate scale decay constant, fa ∼ 10 9÷12 GeV, associated with the small cycles wrappe...

2009
Masafumi Shionyu Akihiro Yamaguchi Kazuki Shinoda Ken-ichi Takahashi Mitiko Go

We have constructed a database, AS-ALPS (alternative splicing-induced alteration of protein structure), which provides information that would be useful for analyzing the effects of alternative splicing (AS) on protein structure, interactions with other bio-molecules and protein interaction networks in human and mouse. Several AS events have been revealed to contribute to the diversification of ...

2013
Chris Walzer Christine Kowalczyk Jake M. Alexander Bruno Baur Giuseppe Bogliani Jean-Jacques Brun Leopold Füreder Marie-Odile Guth Ruedi Haller Rolf Holderegger Yann Kohler Christoph Kueffer Antonio Righetti Reto Spaar William J. Sutherland Aurelia Ullrich-Schneider Sylvie N. Vanpeene-Bruhier Thomas Scheurer

The European Alps harbour a unique and species-rich biodiversity, which is increasingly impacted by habitat fragmentation through land-use changes, urbanization and expanding transport infrastructure. In this study, we identified the 50 most important questions relating to the maintenance and restoration of an ecological continuum - the connectedness of ecological processes across many scales i...

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