Isomaltulose synthase (PalI) catalyzes the hydrolysis of the alpha-1,2 bond between the glucose and fructose moieties of sucrose and the formation of alpha-1,6 and alpha-1,1 bonds between the two components to produce isomaltulose (alpha-D-glucosylpyranosyl-1,6-D-fructofranose) and trehalulose (alpha-D-glucosylpyranosyl-1,1-D-fructofranose), respectively. The PalI protein has been overexpressed...

background: decay products of radon and thoron present in indoor environment are the most important sources of radiation from natural sources which affect human beings, since general public spend at lest 80% of their time in indoor. materials and methods: air samples were collected for measuring the concentration of radon and thoron daughter products from various indoor environments during four...

Two conflicting phenomena, bystander effect and adaptive response, are important in determining the biological responses at low doses of radiation and have the potential to impact the shape of the dose-response relationship. Using the Columbia University charged-particle microbeam and the highly sensitive AL cell mutagenic assay, we show here that non-irradiated cells acquire mutagenesis throug...

Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, reinforcing interest in their clinical development.

Strategies to sensitize human tumors that are resistant to apoptosis have been clinically unsuccessful. We demonstrate that a structurally modified chimeric Pseudomonas exotoxin, PEdelta53L/TGF-alpha/KDEL, with binding specificity for the epidermal growth factor receptor, markedly enhances sensitivity of human xenografts to radiation killing. Exposure to PEdelta53L/TGF-alpha/KDEL decreases the ...

AN INVESTIGATION ON RADON AND THORON RESPONSE OF ALPHA-TRACK DETECTORS USED IN THE WINNIPEG CASE–CONTROL STUDY Jing Chen1,*, Bill Walker1, Atsuyuki Sorimachi2, Hiroyuki Takahashi2 and Shinji Tokonami2 Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, Canada K1A 1C1 Research Center for Radiation Protection, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-...

Radiation-induced bystander effect (RIBE) was first reported by Nagasawa et al. [1] showed that exposure to very low doses of alpha particles initiated sister chromatid exchange in more cells than that could have been hit by an alpha particle as estimated. Thereafter, different biological endpoints, such as chromosomal aberration, sister chromatid exchange, mutation, apoptosis and changes in th...

Two conflicting phenomena, the bystander effect and the adaptive response, are important in determining biological responses at low doses of radiation and have the potential to have an impact on the shape of the dose-response relationship. Using the Columbia University charged-particle microbeam and the highly sensitive AL cell mutagenic assay, we reported previously that nonirradiated cells ac...