Alopecia areata is one of the most common autoimmune diseases resulting from T cell-mediated damage of hair follicles. CD8+ T cells infiltrate hair follicles and are responsible for destruction of hair follicles. However the underlying mechanisms for hair loss remain still obscure. In the present study, we identified that suppressor of cytokine signaling-3 (SOCS3), a classical inhibitor of cyto...

There are numerous dermatoses which may cause cicatricial alopecia when localized on the scalp, such as chronic discoid lupus erythematosus (DLE), lichen planus, graft-versus-host disease, dermatomyositis, scleroderma, cicatricial pemphigoid, porphyria cutanea tarda, follicular mucinosis, perifolliculitis capitis abscedens, lichen sclerosus et atrophicus, necrobiosis lipoidica, sarcoidosis, etc...

Localized scalp hair loss has different causes which alopecia areata, trichotillomania, tinea capitis and early lupus erythematosus are the most important ones. There are several reports of localized alopecia after tick and flea bites and bee stings, but there is only one report of ant-induced alopecia in the literature. We report herein two cases of alopecia induced by ants of genus Phei...

Background: Alopecia areata has a wide range of different clinical presentations. It may present as localized or diffuse hair thinness without hair loss, a small patch of hair loss or may progress to alopecia totalis and universalis. Objectives: Determination of clinical patterns of alopecia areata in Kerman province and to compare the results with other studies in other countries. Patients and...

BACKGROUND Alopecia is one of the most important hair follicle (HF) disorders, which is divided into scarring (cicatricial) and nonscarring (noncicatricial) types. OBJECTIVE The aim of this study is to investigate the expression of stem cell (SC) markers such as cytokeratin (CK) 17 and CK19 in scarring and nonscarring alopecia. MATERIALS AND METHODS Thirty patients with scalp alopecia (15 w...

BACKGROUND Permanent alopecia after bone marrow transplantation is rare, but more and more cases have been described, typically involving high doses of chemotherapeutic agents used in the conditioning regimen for the transplant. Busulfan, classically described in cases of irreversible alopecia, remains associated in recent cases. The pathogenesis involved in hair loss is not clear and there are...

Alopecia areata is a hair loss disorder in humans, dogs and horses with a suspected autoimmune aetiology targeting anagen hair follicles. Alopecia areata is only sporadically reported in cows. Recently, we observed several cases of suspected alopecia areata in Eringer cows. The aim of this study was to confirm the presumptive diagnosis of alopecia areata and to define the clinical phenotype and...

and male alopecia [1–4] . The prerequisite for delivering appropriate patient care is an understanding of the pathologic dynamics of hair loss and a potential multitude of causal relationships. Once the diagnosis is certain, treatment appropriate for that diagnosis is likely to control the problem. Ultimately, the best way to alleviate the emotional distress related to hair loss is to effective...