To evaluate the anti hyperglycemic effect of this new Herbo -Mineral preparation in alloxan induced albino diabetic rats and Acute toxicity studies for this new Herbo -Mineral preparation. Experimental Rats were allowed to fast 24 hrs prior to diabetes ,induced by administration of a single dose of( 120 mg/kg body weight) Alloxan mono hydrate intraperitoneally ,after 24 hours blood was collecte...

Exogenous superoxide dismutase, catalase and scavengers of the hydroxyl radical protect pancreatic-islet cells against the toxic actions of alloxan in vitro [Grankvist et al. (1979) Biochem. J. 182, 17--25]. To test whether the extraordinary sensitivity of islet cells to alloxan is due to a deficiency of endogenous enzymes protecting against oxygen-reduction products, we assayed CuZn-superoxide...

Enamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandi...

Plasma glucose, free fatty acid, ketone, and triglyceride concentrations were measured at frequent intervals after the administration of alloxan to rats. Hepatic triglyceride levels were determined in the same animals. During the second 24-hr period after alloxan administration, severe ketoacidosis developed and triglyceride concentrations in the liver became markedly elevated. This finding was...

Wiihler and Frerichsl fed 5 to 6 grams of this to men but could not recover any in the urine; nor was alloxan found. The urine was rich in urea, and a breaking down of alloxantine to urea and other products was believed to be probable. No mention is made of any toxic effects, although if any had been experienced they would undoubtedly have been described because the subjects were human beings. ...

The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of ethanol extract of Plectranthus amboinicus in normal and alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by single intraperitoneal administration of alloxan monohydrate (150 mg/kg). Normal as well as diabetic rats were divided into groups (n=6) receiving different treatment...

Diabetes mellitus (DM) is a common and serious metabolic disorder throughout the world. Several herbs have been known to cure and control diabetes without any side effects. Corn silk (CS) is one of these herbs that are rich in phenolic and flavonoid compounds that have antioxidant activity. The purpose of this study is to investigate the hypoglycemic and hypolipidemic effect of gamma-irradiated...

The objective of this study was to investigate the single dose antioxidant and antidiabetic effect of a herbomineral amino acid extract (HMAA) of Spinacia oleracea on alloxan induced diabetic rats. In the present study, the animals were divided into 6 groups: Group 1 – Normal saline as vehicle –control, Group 2 – Untreated diabetic rats (Alloxan induced), Group 3 – Animals treated with Metformi...

Numerous indigenous medicinal plants have been found to contain important active principles that make these plants helpful to treat diseases. The present study was conducted to evaluate hypoglycemic and weight stabilizing effects of a compound herbal formulation named Ziabeen in normal and alloxan-diabetic rabbits. Diabetes was induced by alloxan mono hydrate (150 mg/kg body weight, iv.). Blood...

Diabetic neuropathy is a nerve disorder manifested by different faceted condition affecting up to half of individuals with persistent diabetes. Symptoms associated this disease such as palsy, painful polyneuropathy, thoracoabdominal neuropathy, autonomic diabetic amyotrophy, mononeuropathy multiplex, caused motor, sensory, and dysfunction which affects peripheral nervous system, gastrointestina...