The polymorphic variants of CYP1A1 and the deletion GSTM1 are present in Peruvian mestizo population. Wild type mutated genotypes (WT/*2A *2A/ *2A) were identified, whose allele frequencies 0.31 (T allele) 0.69 (C allele), respectively; 53% with wild (+) 47% null . frequency Iquiteño emigrants was 0.72 CYP1A1*2A 25% (-); from Lima 0.67 33% (-). Hardy-Weinberg equilibrium test for studied popula...

2. NEUTRAL EVOLUTION IN ONEAND TWO-LOCUS SYSTEMS 1 The Wright-Fisher Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Loss of Heterozygosity by Random Genetic Drift . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Probabilities and Times to Fixation or Loss . . . . . . . . . . . . . . . . . . . . . . . . ....

background: alzheimer's disease as a neurodegenerative disorder is the commonest type of dementia. a growing number of genes have been reported as the risk factors, which increase the susceptibility to alzheimer's disease. apolipoprotein e ( apoe) , which its ε4 allele has been reported as a risk factor in late onset alzheimer's disease (ad), is the main cholesterol carrier in the brain. the ma...

The frequency of the 235T and 174M alleles of the angiotensinogen gene, previously reported to be associated with hypertension in Caucasians and Japanese, was compared between 57 hypertensive African Americans and 130 normotensive African Americans sampled as part of a community survey of hypertension in the Chicago area. The frequency of the 235T allele was unrelated to hypertension status (ca...

disorder in re-methylation process of homocysteine to methionine due to mutation in betaine homocysteine methyltransferase enzyme (bhmt) coding gene, leads to decrease in s-adenosyl methionine (sam) synthesis which takes part in dna methylation as a methyl donor. as a result, it can promote hypo-methylation of dna, chromosome instability, and chromosome missegregation, which in turn is one of t...

background: survival of the semi-allograft fetus during pregnancy opens a new area for the immunological based causes of recurrent spontaneous abortion (rsa). cytotoxic t lymphocyte-associated antigen 4 (ctla4) is a negative regulator of the t-cell activation, which may modulate peripheral self-tolerance of the allogeneic fetus. the present study aimed to investigate the +49 a/g ctla4 genetic p...