The development of an application based on a set of best software engineering practices involves first their selection. This process may become complex due to the variables involved. This paper presents an Operations Research approach for the selection of best software engineering practices for the development of applications or computational systems considering a series of alternatives and sel...

A bar-and-joint framework is a finite set of points together with specified distances between selected pairs. In rigidity theory we seek to understand when the remaining pairwise distances are also fixed. If there exists a pair of points which move relative to one another while maintaining the given distance constraints, the framework is flexible; otherwise, it is rigid. Counting conditions due...

OBJECTIVES To investigate the validity and feasibility of the Juvenile Arthritis Disease Activity Score (JADAS) in the routine clinical setting for all juvenile idiopathic arthritis (JIA) disease categories and explore whether exclusion of the erythrocyte sedimentation rate (ESR) from JADAS (the 'JADAS3') influences correlation with single markers of disease activity. METHODS JADAS-71, JADAS-...

Smoking, both active and passive, is an established vascular risk factor. The present narrative review considers the effects of different forms of smoking (i.e. cannabis, cigar, pipe, smokeless tobacco and cigarette) on cardiovascular risk. Furthermore, the impact of smoking on several vascular risk factors [e.g. hypertension, diabetes mellitus (DM), dyslipidaemia and haemostasis] and on vascul...

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We present the results of the fully automated CAFASP3 experiment, which was carried out in parallel with CASP5, using the same set of prediction targets. CAFASP participation is restricted to fully automatic structure prediction servers. The servers' performance is evaluated by using previously announced, objective, reproducible and fully automated evaluation methods. More than 60 servers parti...

The classification of loop symmetries in Kitaev's honeycomb lattice model provides a natural framework to study the Abelian topological degeneracy. We derive a perturbative low-energy effective Hamiltonian that is valid to all orders of the expansion and for all possible toroidal configurations. Using this form we demonstrate at what order the system's topological degeneracy is lifted by finite...