PURPOSE We have found that two aspartyl (Asp-151 and Asp-58) residues of alphaA-crystallin are inverted and isomerized to the biologically uncommon D-beta-Asp residues during aging. In order to elucidate the correlation between the formation of the D-beta-Asp isomer and the environment surrounding the Asp in the protein, we performed a Raman spectroscopic study using two synthetic peptides: T6 ...

We present a system (ASP − PROLOG) which provides a tight and well-defined integration of Prolog and Answer Set Programming (ASP). The combined system enhances the expressive power of ASP, allowing us to write programs that reason about dynamic ASP modules and about collections of stable models. These features are vital in a number of application domains (e.g., planning, scheduling, diagnosis)....

Two mild and efficient strategies have been developed for the O-functionalisation of 4-hydroxy-6-alkyl-2-pyrones, by using them as nucleophilic partners in oxa-Michael additions and the Mitsunobu reaction. The reactions proceed in moderate to excellent yields on a range of substrates containing useful functionality. The reactions serve as practical and valuable synthetic methods to construct co...

Two new diarylheptanoids, alpinin A (1) and alpinin B (2), together with 18 known diarylheptanoids (3-20), were isolated from the rhizomes of Alpinia officinarum. Their structures were elucidated by comprehensive spectroscopic analysis, including high-resolution mass spectrometry, infrared spectroscopy, and one- and two-dimensional nuclear magnetic resonance spectroscopy. Structurally, alpinin ...

We present an enhancement of exp(ASP), a system that generates explanation graphs for literal l - atom or its default negation ~a given answer set A normal logic program P, which explain why is true (or false) and P. The new system, exp(ASPc), differs from exp(ASP) in it supports choice rules utilizes constraint to provide include information about choices constraints.

OBJECTIVE Antimicrobial stewardship programs (ASPs) help meet quality and safety goals with regard to antimicrobial use. Prior to CPOE implementation, the ASP at our pediatric tertiary hospital developed a paper-based order set containing recommendations for optimization of dosing. In adapting our ASP for CPOE, we aimed to preserve consistency in our ASP recommendations and expand ASP expertise...

The association of abdominal obesity with cardiovascular risk is often linked to altered secretion of adipose-derived factors and an abnormal lipid profile including formation of atherogenic small dense low density lipoprotein particles (sdLDL). Acylation-stimulating protein (ASP) is an adipose-derived hormone that exhibits potent lipogenic effects. Plasma ASP levels increase in obesity; howeve...

Abstract Aggregates provide a concise way to express complex knowledge. The problem of selecting an appropriate formalization aggregates for answer set programming (ASP) remains unsettled. This paper revisits it from the viewpoint Approximation Fixpoint Theory (AFT). We introduce AFT equivalent with Gelfond–Lifschitz reduct basic ASP programs and we extend handle aggregates. analyze how existin...