This work aims at providing a better understanding of the mechanical properties of the reaction rim in the alkali-silica reaction. The elastic modulus of the calcium alkali silicate constituting the reaction rim, which is formed at the interface between alkali silicate and Ca(OH)₂ in a chemically-idealized system of the alkali-silica reaction, was studied using nano-indentation. In addition, th...

The amyloid protein precursor (APP) of Alzheimer's disease (AD) is abundantly expressed in platelets, where its primary function remains undetermined. As an integral transmembrane protein, the release of APP from the membrane may be a critical event in AD. We examined the association of APP with human platelet membranes using a combination of alkali treatment and immunoprecipitation of the carb...

Program Number: 13 Poster Board Number: A0001 Presentation Time: 8:30 AM–10:15 AM Immunohistochemical observation of meibomian gland following ocular surface alkali burning in wild-type and Smad3-deficient mice Shin Mizoguchi1, Yuka Okada1, Reiko Arita2, Shizuya Saika1. 1Ophthalmology, Wakayama Medical University, Wakayama, Japan; 2Ophthalmology, Itoh Clinic, Saitama, Japan. Purpose: To immunoh...

Chemical burns are a major cause of corneal injury. Oxidative stress, inflammatory responses and neovascularization after the chemical burn aggravate corneal damage, and lead to loss of vision. Although NADPH oxidases (Noxs) play a crucial role in the production of reactive oxygen species (ROS), the role of Noxs in chemical burn-induced corneal injury remains to be elucidated. In the present st...

We report a case of a patient presenting with a triad of hypercalcemia, metabolic alkalosis and renal failure secondary to calcium bicarbonate intake for osteoporosis prevention. It is the classical presentation of the "modern" milk alkali syndrome that presents several characteristics distinguishing it from the "old" syndrome described secondary to peptic ulcer disease treatment. Milk alkali s...

Structural macromolecular parameters of normal and treated (acid & alkali) polyester fibers have been investigated using Small Angle X-ray Scattering (SAXS) technique. Average diameters were calculated from Scanning electron microscope (SEM) micrographs and mechanical parameters were estimated using Instron. Further, crystallinity parameters of the same fibers have been determined using X-ray d...

Metabolic acidosis was one of the earliest complications to be recognized and explained pathologically in patients with CKD. Despite the accumulated evidence of deleterious effects of acidosis, treatment of acidosis has been tested very little, especially with respect to standard clinical outcomes. On the basis of fundamental research and small alkali supplementation trials, correcting metaboli...

A UV-spectrophotometric method is described for the determination of lansoprazole (LAN). The method is based on the measurement of the absorbance of LAN solution in acetonitrile at 281 nm. The system obeyed Beer’s law over the concentration range of 1.2525.0 μg/mL. The degradation behavior of LAN was investigated under dry heat treatment, UV-degradation, acid hydrolysis, alkali hydrolysis and o...

BACKGROUND Alkali burn is a frequently occurring ocular injury that resembles ocular inflammation caused by eye allergies, infection, and refractive surgeries. METHODS We investigated the synergistic regenerative potential of dominant negative survivin mutant (SurR9-C84A) and histone deacetylase (HDAC) inhibitor trichostatin-A (TSA) against alkali burn and corneal haze using human keratocytes...

Linseed oil which has various biomedical applications was encapsulated by chitosan (Chi)-based microcapsules in the development of a suitable carrier. Oil droplets formed in oil-in-water emulsion using sodium dodecyl sulfate (SDS) as emulsifier was stabilized by Chi, and microcapsules with multilayers were formed by alternate additions of SDS and Chi solutions in an emulsion through electrostat...