Chitosan (CS) gel beads were prepared in 10% amino acid solution (pH 9) and implanted into air pouches (AP) prepared subcutaneously on the dorsal surface of mice. No inflammatory response was observed, and degradation of the beads in the AP increased as their degree of deacetylation decreased. Degradation could be altered by changing the nature of the CS or by increasing the CS concentration. T...

The present study has been undertaken to apply the concept of nanoparticulate mucopenetrating drug delivery system for complete eradication of Helicobacter pylori (H. pylori), colonised deep into the gastric mucosal lining. Most of the existing drug delivery systems have failed on account of either improper mucoadhesion or mucopenetration and no dosage form with dual activity of adhesion and pe...

In this current study, aminated graphene oxide (AGO) doped on alginate (Alg) matrix offers AGO@Alg hybrid spheres was developed to investigate its potential for retention of fluoride from water. The sophisticated characterization methods likely TGA, SEM, XPS and FTIR studies were attained recognize physicochemical properties like thermal stability, morphology, elemental binding energy functiona...

Pseudomonas aeruginosa is an opportunistic pathogen that causes a variety of infections in compromised patients. The ability of Pseudomonas aeruginosa to produce chronic infection is based in part on its ability to biosynthesis of biofilm, and alginate is the major polysaccharide in the synthesized biofilm. So alginate degradation is very essential in the dispersion of Pseudomonas aeruginosa bi...

The hybrid hydrogel materials meet important social challenges, including the photocatalytic purification of water and bio-medical applications. Here, we demonstrate two scenarios polyacrylamide-TiO2 (PAAm@TiO2) composite design using calcium alginate (Alg-Ca) or Keplerate-type polyoxometalates (POMs) {Mo132} tuning polymer network structure. Calcium molding allowed us to produce polyacrylamide...

Although selenium nanoparticles (Nano Se) have gained attention for their anti-cancer and antioxidant activity, this nanomaterial's antimicrobial activity also has great potential. The aim of study was to synthesize Nano Se edible coating solution through gamma irradiation technique with a bio-stabilizer sodium alginate (Na-alg.), which is an ingredient commonly used in food preservation. Dynam...

Caenorhabditis elegans contains 25 Argonautes, of which, ALG-1 and ALG-2 are known to primarily interact with miRNAs. ALG-5 belongs to the AGO subfamily of Argonautes that includes ALG-1 and ALG-2, but its role in small RNA pathways is unknown. We analyzed by high-throughput sequencing the small RNAs associated with ALG-5, ALG-1 and ALG-2, as well as changes in mRNA expression in alg-5, alg-1 a...

Marine pollution caused by frequent oil spill accidents has brought about tremendous damages to marine ecological environment. Therefore, the facile large-scale preparation of three-dimensional (3D) porous functional materials with special wettability is in urgent demand. In this study, we report a low-cost and salt-tolerant superoleophobic aerogel for efficient oil/seawater separation. The aer...

The purpose of this study was to evaluate the effect of hydrogel charge affected the behaviors of hepatocytes in vitro. The hydrogel charge was adjusted by tuning the cross-linking between the alginate (Alg) and the poly-L-lysine (PLL). HepG2, a human hepatocyte cell line, was conducted as the cell model. The cellular behaviors on hydrogels were measured by cell morphology observation, viabilit...

Water pollution caused by dyeing wastewater discharge, organic chemical reagent leakage and frequent oil spill incidents has aroused widespread international concern. Various methods have been proposed to remove single pollutant from wastewater. However, it is still a challenging task develop advanced materials that can simultaneously effectively various pollutants In this study, we successfull...