Many studies have found genetic effects to contribute to alcoholism risk in both men and women. Based on preliminary evidence for shared genetic risk between smoking and drinking problems, a reanalysis of alcohol challenge data on 412 Australian twins was performed to explore the possibility that smoking may diminish or moderate the intoxicating effects of alcohol. We found history of smoking t...

The modern conception of alcoholism as a progressive, addictive disease dates from the late 18th century. By the mid-1800s it had become an integral part of American Temperance thought, as did the belief that total abstinence offered the only remedy for intemperance.

Longitudinal analyses allow us to understand how genetic risk unfolds across development, in a way that is not possible with cross-sectional analyses of individuals at different ages. This has received little attention in genetic association analyses. In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from a...

AIMS We examined the relationship between alcohol expectancies in childhood and onset of drinking, binge drinking and drunkenness in adolescence and the influence of drinking onset on expectancy development. DESIGN A prospective, longitudinal study of children assessed for alcohol expectancies and drinking at four time-points between ages 6 and 17 years. SETTING Community study of families ...

PURPOSE This study was to test the reliability and validity of a Drinking Refusal Self-Efficacy Questionnaire-Revised (DRSEQ-R) in Korean college students. METHODS The DRSEQ-R was designed to assess an individual's belief in their ability to refuse drinking alcohol by Oei et al. (2005) and consisted of three factors (social pressure, opportunity, and emotional relief). A methodological study ...

Drunk driving, a major contributor to alcohol-related mortality, has been linked to a variety of other alcohol-related (e.g., Alcohol Dependence, early age at first drink) and non-alcohol-related externalizing behaviors. In a sample of 517 same-sex twin pairs from the National Longitudinal Study of Adolescent Health, we examined 3 conceptualizations of the etiology of drunk driving in relation ...

BACKGROUND Previous research has suggested important contextual factors that can differentiate problem and nonproblem drinkers. OBJECTIVES To evaluate the strength of the prospective association between social contexts of drinking and subsequent alcohol use disorder and drunk driving 2-3 years later. METHODS The sample consisted of 652 individuals who were originally recruited at college en...

BACKGROUND Consumption of alcohol is associated with acute and chronic adverse health outcomes. There is a paucity of studies that explore the determinants of alcohol use among adolescents in sub-Saharan Africa and, in particular, that examine the effects of adverse childhood experiences on alcohol use. METHODS The paper draws on nationally-representative data from 9,819 adolescents aged 12-1...

In order to investigate whether alcohol-withdrawal kindling is an irreversible process, male Wistar rats were exposed to 12 episodes, each consisting of 2 days of severe alcohol intoxication and 5 days of alcohol withdrawal. Spontaneous withdrawal seizures were found in 15% of the animals during episodes 10-12. After an alcohol-free period of 26 days, the animals were subjected to three more ep...

The Criminal Code of 1902 was in effect until October 2015, and has consequently framed Norwegian criminal law for more than a Century. The code was originally part of a larger penal reform and pivotal in Norwegian socialand criminal policy-making at the turn of the century. The Law Professor Francis Hagerup (1853-1921) emphasised the year before the code was adopted that the reform did not onl...