Glutathione and disease GSH is the most abundant intracellular non-protein thiol and has been implicated in many cellular functions including detoxification, synthesis, cell-cycle regulation, regulation of gene expression, protection of proteins and other cellular components, and as an antioxidant [l-41. It can scavenge free radicals and electrophiles nonenzymically, as well as detoxify xenobio...

objective: crocin is an active ingredient of saffron (crocus sativus l.) and its antioxidant properties have been previously investigated. this carotenoid scavenges free radicals and stimulates glutathione (gsh) synthesis; consequently, it may protect cells against oxidative stress. the aim of this research is to protect oocytes from oxidative stress by the addition of a natural source antioxid...

Free radicals are implicated in several diseases of prematurity. The study aimed to correlate plasma antioxidants levels and lipid peroxidation between maternal and cord blood in normal and preterm deliveries. Superoxide dismutase (SOD), Reduced Glutathione (GSH) and Uric acid were the measured antioxidants while Malondialdehyde (MDA) was an index of lipid peroxidation. 32 mothers who delivered...

Abstract Background Cadmium (Cd) pollution has brought harm to the growth and development of potato. Glutathione (GSH) is an important antioxidant that may play active role in response a potato Cd stress. However, how GSH influences effect on potatoes unknown. In this study, we investigated effects exogenous phenylpropanoid biosynthesis pathway plant hormone signal transduction under stress exp...

Kombu RS, Zhang GF, Abbas R, Mieyal JJ, Anderson VE, Kelleher JK, Sanabria JR, Brunengraber H. Dynamics of glutathione and ophthalmate traced with H-enriched body water in rats and humans. Am J Physiol Endocrinol Metab 297: E260–E269, 2009. First published April 28, 2009; doi:10.1152/ajpendo.00080.2009.—We developed a LC-MS-MS assay of the H labeling of free glutathione (GSH) and bound glutathi...

PURPOSE Bisretinoids such as A2E that accumulate as components of the lipofuscin of retinal pigment epithelial cells are implicated in some retinal disease processes. These compounds undergo light-induced oxidation and cleavage with the latter releasing of a mixture of aldehyde-bearing fragments, including dicarbonyl methylglyoxal. We tested for the reactivity of photooxidation and photodegrada...

The ubiquitous tripeptide glutathione (GSH) has previously been shown to be mutagenic to Salmonella typhimurium TA100 when incubated with kidney subcellular fractions at physiological concentrations (Glatt et al., 1983). Here we report that the mutagenic effect of GSH can be inhibited by the use of the gamma-glutamyl-transpeptidase (gamma-GT) inhibitor anthglutin and by the metal chelators bath...

College student alcohol abuse remains a significant public health problem, and there is a need for theory-driven and empirically based models to guide prevention efforts. Behavioral theories of choice assume that the decision to consume alcohol is influenced by the relative value of alcohol versus other available activities. In the present study, a sample of college student drinkers (N=108; 56%...

Background The chronic postischemia pain (CPIP) model is an animal model using ischemia/reperfusion injury that mimics the symptoms of complex regional pain syndrome type I. Glutathione (GSH) prevents ischemia/reperfusion injury by scavenging free radicals. We conducted this study to investigate the protective effect of GSH in CPIP rats via changes of mechanical allodynia and phospholyration of...

The tripeptide y-glutamyl-cysteinyl-glycine. or glutathione. protects cells against oxidative damage by its ability to react with free radicals and peroxides. From studies with human neutrophilic granulocytes deficient in glutathione metabolism. it is known that the protection by this compound is essential for the proper functioning of these cells. Previous studies have yielded conflicting esti...