The purpose of this chapter is to review the literature on attendance at professional sporting events. In addition, rational addiction models and theories will be surveyed. There is an abundant literature on both of these topics, and each will be discussed based on its relevance to the present research on rational addiction among fans of the National Football League (NFL). First, the chapter wi...

The importance of the GABA-benzodiazepine receptor complex and its subtypes are increasingly recognised in addiction. Using the α1/α5 benzodiazepine receptor PET radioligand [(11)C]Ro15 4513, we previously showed reduced binding in the nucleus accumbens and hippocampus in abstinent alcohol dependence. We proposed that reduced [(11)C]Ro15 4513 binding in the nucleus accumbens was a marker of add...

Alcohol and other drugs of abuse, including psychostimulants and opioids, can induce epigenetic changes: a contributing factor for drug addiction, tolerance, and associated withdrawal symptoms. DNA methylation is a major epigenetic mechanism and it is one of more than 200 methylation reactions supported by methyl donor S-adenosylmethionine (SAM). Levels of SAM are controlled by cellular redox s...

Alcoholism is characterized by successive periods of abstinence and relapse, resulting from long-lasting changes in various circuits of the central nervous system. Accumulating evidence points to the endocannabinoid system as one of the most relevant biochemical systems mediating alcohol addiction. The endocannabinoid system regulates adult neurogenesis, a form of long-lasting adult plasticity ...

Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to stop or control alcohol use despite adverse consequences. A main challenge of treatment prevent relapse, which occurs in more than >50% newly abstinent patients with disorder within 3 months. In people suffering from addiction, stressful events, drug-associated cues and contexts, re-exposure small amo...

introduction: behavioral science experts believe that all entities capable of stimulating a person can be addictive; and whenever a habit changes into an obligation, it can be considered as an addiction. researchers also believe that there are a number of similarities as well as some differences between drug addiction and behavioral addiction diagnostic symptoms. the purpose of this study is to...

Alcohol abuse is associated with long-term reductions in fronto-cortical volume and limbic metabolism. However, an unanswered question in alcohol research is whether these alterations are the sole consequence of chronic alcohol use, or contain heritable contributions reflecting biological propensity toward ethanol addiction. Animal models of genetic predisposition to alcohol dependence can be u...

First, let me say that I am a doctor specializing in alcohol and drug studies and the author of over a hundred publications so I have a good perspective of science books, etc. In a sentence, Carl Ericksons book, The Science of Addiction is one of the best books ever published on the subject. Anyone in the field of addiction medicine (e.g., physicians, psychologists, drug/alcohol counselors) or ...

All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Can adian Medical Association. A lcohol use disorders, defined as clinic­ ally significant impairment or distress from the use of alcohol, are common in Canadian society. 1 In addition, 15% to 20% of Canadians who do not meet the criteria for an alcohol use disorder drink more than what is recom...