I n t e r v e n t i o n 36 children were allocated to a single dose of oral dexamethasone, 1 mg/kg, and 34 were allocated to placebo. At 0, 30, 60, and 120 minutes, all children received albuterol (Ventolin 5% solution, GlaxoSmithKline, Research Triangle Park, NC, USA) via nebulizer, 2.5 mg per dose (0.5 mL) in 3 mL normal saline and oxygen flow 6 to 7 L/min. After a 4-hour observation period, ...

A 47-year-old woman presented to the emergency department complaining of 2 days of increasing shortness of breath despite escalating use of albuterol by metered-dose inhaler (MDI). She had a long history of bronchial asthma, including one hospital admission for status asthmaticus with respiratory failure requiring intubation and ventilatory support. That hospitalization had been complicated by ...

Study objective: Systemic administration of P-agonist and anticholinergic drugs markedly impair normal autonomic heart rate control. The purpose of this study was to quantify and compare the effects of therapeutic doses of inhaled albuterol and ipratropium on autonomic control of the cardiovascular system. Design: Randomized, double-blind, placebo-controlled, crossover design study. Setting: Te...

A simple, rapid, gradient reversed phase Ultra Performance Liquid Chromatographic method with ultraviolet detection (UPLC-UV) was developed for analysis of Albuterol sulfate and its impurities in Albuterol sulfate inhalation solution pharmaceutical formulation. Chromatography was carried out on a Waters Acquity BEH C18 (1.7μm, 100mm.x 2.1mm) column using 0.02 M Potassium Dihydrogen Orthophospha...

OBJECTIVES To examine the use of intravenous magnesium in Canadian pediatric emergency departments (EDs) in children requiring hospitalization for acute asthma and association of administration of frequent albuterol/ipratropium and timely corticosteroids with hospitalization. METHODS Retrospective medical record review at 6 EDs of otherwise healthy children 2 to 17 years of age with acute ast...

BACKGROUND The aim of this study was to investigate the effects of different delivery circuit configurations, nebulizer positions, CPAP levels, and gas flow on the amount of aerosol bronchodilator delivered during simulated spontaneous breathing in an in vitro model. METHODS A pneumatic lung simulator was connected to 5 different circuits for aerosol delivery, 2 delivering CPAP through a high...

BACKGROUND Nebulized drug delivery is a cornerstone of therapy for obstructive lung disease, but the ideal nebulizer design is uncertain. The breath-actuated nebulizer (BAN) may be superior to conventional nebulizers. This study compared the BAN to standard nebulizer with regard to efficacy, safety, and patient and respiratory therapist (RT) satisfaction. METHODS Adults admitted to the hospi...