Catecholamine neurotransmitters are synthesized by hydroxylation of tyrosine to L-dihydroxyphenylalanine (L-Dopa) by tyrosine hydroxylase (TH). The elimination of TH in both pigmented and albino mice described here, like pigmented TH-null mice reported previously (Kobayashi et al., 1995; Zhou et al., 1995), demonstrates the unequivocal requirement for catecholamines during embryonic development...

Background: The glutamate system has been implicated in depression recently. This is a departure from previous thinking, which had focused on serotonin and norepinephrine. The glutamate system may represent a new avenue for treatment and research. NMDA and AMPA are receptors for the neurotransmitter glutamate. Blocking NMDA increases the activity of another receptor, AMPA, and this boost in AMP...

Introduction: Depression disorder has significant potential morbidity and mortality, contributing to suicide, incidence adverse outcomes of medical illness, disruption in interpersonal relationships, substance abuse, lost work time. Objectives: The present study was designed the anti-depressant activity seeds extract Zanthoxylum armatum using a forced swim test tail suspension on Swiss albino m...

Objectives: The primary objective of this study was to assess the pharmacological activity Cinnamaldehyde (CA) obtained from cinnamon bark in 7, 12-Dimethylbenz antharacene (DMBA)-induced skin cancer albino mice and important cell antioxidant enzymes levels which play an role cancer. Methods: Cinnamon collected obtain CA phytochemical screening extract performed. Then done with cancer, after 12...

Objectives: The study is planned to investigate the antidiabetic activity of hesperidin on Streptozotocin (STZ)-induced diabetes mellitus in Swiss Albino mice. Materials and Methods: mice were divided into six groups viz., normal control, diabetic insulin 0.75 IU/kg, 100, 200 400 mg/kg, respectively (n = 6/group). All received treatments once daily for 21 consecutive days, except control groups...

Abstract: Background: Bacterial meningitis is a serious medical disorder that should be treated as soon possible. Aim: The effect of ansamycin nanoformulation on Escherichia coli induced was investigated. Materials and Methods: By injecting directly into the brains Swiss Albino mice, an experimental model established. Results: As expected, TNF-α, IL-6, IL-10 secretion stimulated, following neut...

The present study was carried out to elucidate the potential of, chloroform extract of Pandanus (P.) fascicularis Lamk (Family-Pandanaceae) leaves on antinociceptive, behavioral study and antiinflammatory effects using various animal models The dried, powdered leaves of, P. fascicularis were extracted successively with petroleum ether (60 80°C) and chloroform in soxhlet apparatus. The chlorofor...