Background: The reported statistics suggest that alcoholic liver disease is on the rise. Furthermore, medications used to treat have unpleasant effects, and this necessitates need continuously investigate hepatoprotective agents. This study investigates animal models of evaluate activity. Content: A good number published articles evaluating activity were summarized. studies three ethanol-induce...

This study was carried out to investigate the effect of alcoholic extract of Lagerstroemia speciosa (L) pers. against carbon tetrachloride (CCl4) induced liver fibrosis in male albino Wistar rats (150-200gm). Liver fibrosis was induced by twice/week administration of CCl4 at a dose of 1ml/kg body weight, mixed with an equal volume of corn oil. The extent of liver fibrosis was assessed by the co...

dacarbazine/placebo (HR = 0.76 [0.63–0.93]; P = 0.006). Rates of adverse events (AEs) were higher with ipilimu mab/dacarbazine and were consistent with those found in previous studies. Most AEs were immune-based and were responsive to dose interruptions or discontinuations, corticosteroids, or other immunosuppressants. Dr. Wolchok noted that although rates of diarrhea (overall, 35.4%; grade 3–4...

Liver disease has become a global concern worldwide. In absence of reliable liver protective drugs in modem medicine, a large number of medicinal preparations are recommended for the treatment of liver disorders as they are believed to be harmless based on their natural origin. The aim of the present study was to determine the hepatoprotective activity of Phyllanthus amarus plant extract agains...

Parinari curatellifolia is a valuable and cherished medicinal plant in which different parts of the plant are widely used by the traditional herbalist in the treatment of many diseases. Effect of methanolic leaf extract of P. curatellifolia on the liver and kidney of albino rats was investigated. Different doses of 100, 200, 300 and 400 mg/kg/bw of the crude extract were administered to rats da...

The biochemical effects of ethylacetate extract of wheat (Avemar) on some serum and liver enzymes were evaluated in T. brucei infected rats. The results show significant increase in specific activities of serum aspartate transaminase (AST) in infected untreated rats when compared with infected treated rats. However, there were no significant difference in serum and liver alanine transaminase (A...

In this study, alterations in glucose, blood enzymes (alkaline phosphatase (ALP), lactate dehydrogenase (LDH), alanine transaminase (ALT), aspartate aminotransferase (AST)) and serum ion (P, Mg, Cl, Ca, Fe) levels were investigated in Tilapia (Oreochromis mossambicus), which were semi-statically exposed to different lead concentrations in vivo. The fish were exposed to low (0.5 mg/L), medium (2...

Background: There is substantial evidence that environmental factors cause or accelerate the onset of malignancy. Environmental factors, due to the presence of many pollutants and carcinogenic agents, alter cellular growth, which leads to biochemical changes in the blood. Materials and Methods: In the present study, we estimated serum pseudocholinesterase (PCHE), serum aspartate transaminase (A...

BACKGROUND One of the features associated with pre-eclampsia is elevated liver transaminases. The reason this happens has not been fully described. However, the hepatocytes are not known to be spared by free radical injury. This study was conducted to examine the relationship between product of free radical injury (malondialdehyde) and transaminases in pre-eclamptic women. PATIENTS AND METHOD...

INTRODUCTION Myopathy related to systemic sclerosis (Myo-SSc) is a disabling and unpredictable complication of SSc. We assessed the predictive value of serum aldolase, creatine kinase (CK), alanine transaminase (ALT), aspartate transaminase (AST) and C-reactive protein (CRP) to estimate the risk of developing Myo-SSc. METHODS We enrolled 137 SSc patients without proximal muscle weakness in a ...