Mutant phagosomes bite off more than they can chew A kbar et al. reveal that the fl y homologue of a gene mutated in human disease encodes a protein required for phagosome matura-tion and digestion of pathogens. The HOPS complex is a multi-subunit tethering factor that regulates vacuole fusion in budding yeast. Metazoans express two versions of the HOPS subunits Vps16p and Vps33p. Vps16A and Vp...

' The first class, in the lustre of their star, perceive the mysteries of the external and the internal, and in their understanding and the breadth of their views fully comprehend both realms of thought and acknowledge to have received their spiritual power from the throne ?f His Majesty. 1 The second class pay less attention to the external world; but in the light of their hearts they acquire ...

Atmosphere modification by reducing oxygen or increasing carbon dioxide has been used widely in recent years as a chemical-free strategy for managing stored-product pest insects (Donahaye et al. 1996; Adler et al. 2000; Jayas and Jeyamkondan 2002). The red flour beetle, Tribolium castaneum (Herbst), being among the most problematic of stored-product insects, has been the subject of considerable...

The elderly can't fend off infections as vigorously as they once could. Agius et al. now show that part of the problem—at least in the skin—stems from memory T cells that can't get to their destination. People have sluggish immune responses as they grow old, so it was of little surprise to Agius and colleagues that lymphocytes didn't rush to the site of antigen injection in the skin of people o...

As an Islamo-Arabic utterance,throughout the history of Islam, “Allahu Akbar” has been widely used as one of the most influential religious slogans since the advent of Islam in the 7th century CE. However, during the last four decades, it has gained a fairly global reputation thanks to various functions it has pragmatically come to serve in different social settings. Recentl...

AbstractThis research aims to determine the main factors underlying glory of Mughal Islamic empire by using a qualitative approach with descriptive method. Methods data collection literature study books and ebooks. The results prove that: Jalaluddin Muhammad Akbar was first Muslim ruler who able maintain his position in long time, not merely fulfill personal ambitions but take advantage as king...