(1995) Peer review of risperidone in the treatment of patients with chronic schizophrenia a multinational , multi-centre, double-blind, parallel-group study versus haloperidol.(1998) Alteration in the recommended dosing strategy for risperidone. REPLY Sir, Kindly refer to the comments of Duggal and Nizamie on our paper. We are grateful to them for the interest shown in our paper. Our responses ...

Tardive dyskinesia (TD), characterized by oro-buccal-lingual stereotypy, can manifest in the form of akathisia, dystonia, tics, tremor, chorea, or as a combination of different types of abnormal movements. In addition to movement disorders (including involuntary vocalizations), patients with TD may have a variety of sensory symptoms, such as urge to move (as in akathisia), paresthesias, and pai...

Results In themixed-effects repeatedmeasures analysis, improvement from baseline onthe Scale of Prodromal Symptoms total scorewas statistically significant by the first week.No participantconverted to psychosis and 13 completed treatment.Neuropsychologicalmeasures showedno consistent improvement; meanweight gainwas1.2 kg.Akathisia emerged in 8 participants, butthemean Barnes Akathisia Scale sco...

BACKGROUND The main aims of the programme were to highlight the incidence of adverse reactions to the drugs monitored and to define the risk/benefit ratio taking account of the main physiological and physiopathological variations of patients. This paper reports the results of the programme regarding to adverse effects correlated to the use of some psychiatric drugs (benzodiazepines and neurolep...

PURPOSE To examine the relation between variant alleles in 3 CYP450 genes (CYP2D6, CYP2C9 and CYP2C19), interacting drugs and akathisia in subjects referred to a forensic psychiatry practice in Sydney, Australia. PATIENTS AND METHODS This paper concerns 10/129 subjects who had been referred to the first author's practice for expert opinion or treatment. More than 120 subjects were diagnosed w...