Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD). Characteristics of COPD are airway obstruction, airway inflammation and airway remodelling, processes encompassed by increased airway smooth muscle mass, epithelial changes, goblet cell...

OBJECTIVE To examine the prevalence of airway involvement in children with Wegener's granulomatosis (WG) at our institution and to evaluate the utility of a treatment paradigm involving a multidisciplinary team. DESIGN Retrospective medical chart review. SETTING Tertiary children's hospital. PATIENTS Pediatric subjects with WG treated at a tertiary children's hospital over the past 15 yea...

RATIONALE Bronchodilator responsiveness (BDR) is a common but variable phenomenon in COPD. The CT characteristics of airway dimensions that differentiate COPD subjects with BDR from those without BDR have not been well described. We aimed to assess airway dimensions in COPD subjects with and without BDR. METHODS We analyzed subjects with GOLD 1-4 disease in the COPDGene® study who had CT airw...

The term asthma-COPD overlap syndrome (ACOS) is one of multiple terms used to describe patients with characteristics of both COPD and asthma, representing ~20% of patients with obstructive airway diseases. The recognition of both sets of morbidities in patients is important to guide practical treatment decisions. It is widely recognized that patients with COPD and coexisting asthma present with...

the laryngeal mask airway (lma) is an important addition to the anesthetist's equipments. however, its usage may involve some complications. we have encountered an unusual and potentially serious complication using this equipment. a 45-year old man underwent cataract surgery under general anesthesia. after the induction of anesthesia, a size 4 of the reusable classic lma was inserted without an...

reinforced tubes are commonly used to minimize the opportunity of upper airway obstruction in patients at risk. there are a few reports of the airway obstruction resulted from kinked reinforced tubes. this report describes the obstruction of a reinforced tube in an adult patient who underwent tonsillectomy. under general anesthesia; an armoured endotracheal tube was inserted into the trachea un...

Introduction Benign airway stenosis (BAS), namely narrowing caused by a variety of benign lesions, can lead to varying degrees breathing difficulties and even death due asphyxia. This study aimed elucidate the clinical characteristics BAS, including etiology, treatment pathology, analyzing data BAS patients. Methods A retrospective analysis was conducted using 617 cases from January 2017 Decemb...

Background and purpose: Transverse problems in the maxilla (high arched- narrow hard plates) can cause respiratory disorders. Palatal expansion can be helpful in this way. The present study aimed at evaluating the effect of bone borne expansion and tooth borne palatal expansion on airway volume. Materials and methods: A review study was performed by search in Google Scholar, Scopus, PubMed, Em...

the widespread use of sulfur mustard  (sm) as a chemical warfare agent in the  past century has proved its long-lasting toxic effects. despite a lot of research over the past decades on iranian veterans, there are still major gaps in the sm literature. transforming growth  factor  (tgf-β),  a  cytokine  that  affects  many  different  cell processes,  has  an important role in the lungs of pati...