MicroRNAs play important roles in cell differentiation by acting as translational inhibitors of specific target genes. Here we show that human granulocytic differentiation is controlled by a regulatory circuitry involving miR-223 and two transcriptional factors, NFI-A and C/EBPalpha. The two factors compete for binding to the miR-223 promoter: NFI-A maintains miR-223 at low levels, whereas its ...

MicroRNAs (miRNAs) present frequently altered expression in urologic cancers including prostate, bladder, and kidney cancer. The altered expression of miR-223 has been reported in cancers and other diseases in recent researches. MiR-223 is up-regulated in systemic lupus erythematosus and rheumatoid arthritis. In neoplastic diseases, miR-223 is proved to be up-expressed in plasma or serum and ca...

Spent or disused sealed radiation sources—no longer needed sources—may represent a risk of radiological accident or may be a target for criminal acts in countries where final disposal options are unavailable and where an increasing number of sources are being kept in extended storage. In developing countries, thousands of radium needles, teletherapy sources, oil well logging neutron sources, an...

The adsorption and desorption of paraquat (1, l'-dimethyl-4,4'-dipyridylium dichloride) in two tropical soils was determined under laboratory conditions. The two soils were taken from rice fields located in the North West of Perak state. The adsorption equilibrium time was 2 hours for both soil types. This adsorption equilibrium time was used to determine the effect of concentration on adsorpti...

The reaction of MgCl(2), NiCl(2), and Na(2)(i-mnt) (i-mnt is 1,1-dicyano-thene-2,2-dithiol-ate) with 15-crown-5 (15-C-5) leads to an infinite chain polymer, {[NiMg(2)(C(4)N(2)S(2))(2)(C(10)H(20)O(5))(2)]Cl(2)}(n) or {[Mg(15-C-5)](2)[Ni(i-mnt)(2)]Cl(2)}(n), which consists of two [Mg(15-C-5)](2+) complex cations, one [Ni(i-mnt)(2)](2-) complex anion and two Cl(-) ions per formula unit. In the [Ni...

Background Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, such as radium-223, is not established. Patients and methods The radium-223 ALSYMPCA trial enrolled patients with CRPC and symptomatic bone metastases. Prognostic potential of ...

BACKGROUND The mechanism for inactivation of positive regulatory domain containing I (PRDM1), a newly identified tumour suppressor gene in extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT) has not been well defined. The aim of the present study was to investigate the expression of PRDM1 in EN-NK/T-NT and analyse its downregulation by miRNAs. METHODS PRDM1 and miRNA expression were evalua...

objective: micrornas (mirna) are a class of non-coding rnas which play key roles in post-transcriptional gene regulation. previous studies indicate that mirnas are dysregulated in patients with multiple sclerosis (ms). th17 and regulatory t (treg) cells are two subsets of cd4+ t-cells which have critical functions in the onset and progression of ms. the current study seeks to distinguish fluctu...