The role of the thymus in the induction of tolerance to peripheral antigens is not yet well defined. One impending question involves how the thymus can acquire the diversity of peripheral nonthymic self-Ags for the process of negative selection. To investigate whether peripheral Ags are synthesized in the thymus itself, we have determined the expression of a panel of circulating and cell-bound ...

Autoantibodies are often detected in hepatocellular carcinoma (HCC), and these responses may represent recognition of tumor Ags that are associated with transformation events. The identities of these Ags, however, are less well known. Using serological analysis of recombinant cDNA expression libraries (SEREX) from four HCC patients, we identified 55 independent cDNA sequences potentially encodi...

The repertoires of CD1- and MHC-restricted T cells are complementary, permitting the immune recognition of both lipid and peptide Ags, respectively. To compare the breadth of the CD1-restricted and MHC-restricted T cell repertoires, we evaluated T cell responses against lipid and peptide Ags of mycobacteria in leprosy, comparing tuberculoid patients, who are able to restrict the pathogen, and l...

In this talk some of the latest data on directed sideward, elliptic, radial, and longitudinal flow at AGS energies will be reviewed. A method to identify the reaction plane event by event and the measurement of its resolution will be discussed. The distributions of global observables (transverse energy ET and charged particle multiplicity Nc), as well as those of identified particles will be sh...

Anecdotes have emerged in the media about why state attorneys general run for higher office, but there have been no empirical examinations of why some attorney generals (AGs) run for higher office and others do not. I seek to answer two questions: first, what shapes political ambition among state AGs? Second, how do styles of policy making affect the likelihood of AGs running for higher office?...

We compared mitochondrial function, morphology, and proteome in the rat normal gastric cell line RGM-1 and the human gastric cancer cell line AGS. Total numbers and cross-sectional sizes of mitochondria were smaller in AGS cells. Mitochondria in AGS cells were deformed and consumed less oxygen. Confocal microscopy indicated that the mitochondrial inner membrane potential was hyperpolarized and ...

Current extensive research on aerobic granular sludge (AGS) largely focuses improving its microbial biodiversity, settlement behavior, nitrogen and phosphorus removal efficiency, shock load resistance. Great challenges that have to be faced are the bottleneck of slow-speed granulation easy disintegration after granulation, which key extended application AGS technology. In present review, typica...

The expression of activated cell antigens (Ags) on adult T cell leukemia (ATL) cells at different clinical stages (acute, chronic, and smoldering), and ATL cells from enlarged lymph nodes were studied using monoclonal antibodies (MoAbs). The expressions of CD25 (Tac), CD28, T9 (transferrin receptor), and Ki-67 (proliferating cell nuclear antigen) Ags were high, and that of CD7 Ag was low in bot...

The anaerobic isolation of anginosus group streptococci (AGS) from respiratory specimens containing diverse microbiota using a semiselective blood agar medium incorporating nalidixic acid and sulfamethazine (NAS) is described. AGS were detected in 60% of tested sputa from patients with cystic fibrosis, chronic obstructive pulmonary disease, and bronchiectasis. This demonstrates NAS to be a diag...