An Bras Dermatol. 2017;92(6):891-900. According to the literature, hospitalization is required in some cases, which did not happen in our case because of the early intervention (Table 2).5 Considering a reduced risk of agranulocytosis development and in accordance with Carneiro et al. (2011),5 our aim was not to question DDS therapy for leprosy, but to stimulate clinical awareness of its risks ...

An alcoholic woman who was admitted to hospital for detoxification was prescribed thyroxine because of hypothyroidism and mianserin to alleviate severe depression. After several weeks' treatment she became unwell and was readmitted to hospital. Haematological examination indicated agranulocytosis. Further extensive investigations elicited no cause for this other than the mianserin, since no suc...

Drug-induced immune system mediated agranulocytosis is a rare but potentially life-threatening condition. There have been only a few reports on the drug-induced agranulocytosis during pregnancy. We present a case of agranulocytosis after prolonged intravenous infusion of ritodrine hydrochloride and additional administration of indomethacin suppositories, effectively treated using recombinant hu...

We studied several factors that may influence the duration of hematologic recovery to reach neutrophil counts (>0.5 and 1.5×109/L) and thus, indirectly, the prognosis in 91 patients with well-established drug-induced agranulocytosis. Multivariable analysis showed that neutrophil count <0.1×109/L and infection profile (severe infections or septic shock) adversely influenced the neutrophil recove...

AGRANULOCYTOSIS is fortunately a rare condition but, nevertheless, the' following three cases, all of which were seen within a period of fifteen months, illustrate the necessity of keeping it in mind when endeavouring to arrive at a diagnosis. The importance of the oral manifestations of this symptomcomplex were emphasized by Mark (1934) who stated: "The frequency of the mouth lesions as the fi...

OBJECTIVE To report on an uncommon association of agranulocytosis in primary Sjögren's syndrome (SS). METHODS The clinical, haematological, and immunological features of seven patients with primary SS associated with a chronic (>6 months) agranulocytosis, and the outcome of the patients, were analysed. RESULTS Patients were white women with an unexplained agranulocytosis. They all had non-e...

An infant with an alloimmune agranulocytosis whose granulocyte count temporarily returned to normal during intravenous, high dosage immunoglobulin treatment is described.