conclusions there were diverse phenotypic changes among vancomycin-non-susceptible s. aureus isolates. this may be due to the variety of related regulatory systems. the diversity of phenotypic expression may result in its misidentification in routine laboratory checks. materials and methods a total of 130 methicillin-resistant s. aureus (mrsa) isolates were studied, including 49 vssa, 28 hvisa,...

To the Editor—We read the study by Shopsin et al. [1] with interest. As far as we are aware, this study provides the first accessory gene regulator (agr) functional analysis for isolates of Staphylococcus aureus recovered from colonized individuals. These authors observed that agrdysfunctional isolates colonized 15 (9%) of 160 screened subjects and suggest that agr-dysfunctional strains were fi...

BACKGROUND The effects of vasectomy on spermatogenesis and reproductive parameters are recognized to be specie-dependent with marked differences in levels of perturbations observed. OBJECTIVES To assess the impact of unilateral vasectomy on testosterone level and other testicular parameters in the male African giant rat (AGR) (Cricetomys gambianus). METHODS Sixteen adult male AGRs weighing ...

This study investigates the feasibility of developing an Artificial General Recommender (AGR), facilitated by recent advancements in Large Language Models (LLMs). An AGR comprises both conversationality and universality to engage natural dialogues generate recommendations across various domains. We propose ten fundamental principles that should adhere to, each with its corresponding testing pro...

Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.

The expression of many virulence determinants in Staphylococcus aureus including alpha-hemolysin-, protein A-, and fibronectin-binding proteins is controlled by global regulatory loci such as sar and agr. In addition to controlling target gene expression via agr (e.g. alpha-hemolysin), the sar locus can also regulate target gene transcription via agr-independent mechanisms. In particular, we ha...

BACKGROUND Chronic inflammation is known to be one of the main steps in carcinogenesis. Identification of those with chronic inflammation may help identify subjects at risk of cancer. Previous studies have reported low albumin-to-globulin ratio (AGR) to be associated with increased cancer mortality in cancer patients, but there has been no study based on healthy populations. PATIENTS AND METH...

The goal of this work was to determine whether staphylococcal enterotoxin type A gene (sea) expression is regulated by an accessory gene regulator (agr). The Tn551 insertionally inactivated agr allele of Staphylococcus aureus ISP546 was transferred to three Sea+ S. aureus strains. Each of the Agr- strains produced as much staphylococcal enterotoxin A (SEA) as its parent strain. These results su...

Repression of virulence by Staphylococcus aureus strains from different Agr groups has been demonstrated in vitro and is proposed as a means of competitive interference. Here, using the insect Manduca sexta, we show for the first time that this interference also occurs in vivo within a mixed population.