OBJECTIVE To review the available knowledge on the use of GnRH agonist for ovulation triggering as a means to prevent ovarian hyperstimulation syndrome (OHSS). DESIGN(S) Review of pertinent English language studies published over the past 15 years. RESULT(S) The available literature suggests that while GnRH agonist effectively induces final oocyte maturation and ovulation, it also completel...

Photodynamic therapy uses a combination of light, oxygen, and a photosensitizer to induce the death of malignant cells. To improve the selectivity of a photosensitizer toward cancerous cells that express gonadotropin-releasing hormone (GnRH) receptors, protoporphyrin IX (PpIX) was conjugated to a GnRH agonist, [d-Lys6]GnRH, or to a GnRH antagonist, [d-pGlu1, d-Phe2, d-Trp3, d-Lys6]GnRH. The con...

longer half-life [ 24 h versus 60 min for LH (Yen et al., A new treatment option for patients undergoing ovarian 1968; Damewood et al., 1989)], HCG administration results stimulation is the gonadotrophin-releasing hormone in a prolonged luteotrophic effect, characterized by the develop(GnRH) antagonist protocol, with the possibility to trigger ment of multiple corpora lutea and supraphysiologic...

Background: The long protocol has been recognized as the gold standard in controlled ovarian hyperstimulation (COH). However, full dose of gonadotropin-releasing hormone agonist (GnRH-a) under prolonged become increasingly popular China. This study sought to compare pregnancy outcomes among following 3 groups: a group, and 2 types improved groups.

R.H.Mehta1 and T.C.Anand Kumar cysts remains unclear. Three hypotheses have been proposed to explain this phenomenon: Hope Infertility Clinic, Reproductive Health Clinic And Research Centre, 12 Aga Abbas Ali Road, Bangalore 560 042, India Hypothesis I 1To whom correspondence should be addressed Commencement of GnRH agonist, either as a single dose of This debate was previously published on Webt...

BACKGROUND Despite the clinical outcomes of ovarian stimulation with either GnRH-agonist or GnRH-antagonist analogues for in vitro fertilization (IVF) being well analysed, the effect of analogues on oocyte/embryo quality and embryo development is still not known in detail. The aim of this case-control study was to compare the efficacy of a multiple-dose GnRH antagonist protocol with that of the...

Gonadotropin-releasing hormone (GnRH) and its agonists have been known to directly affect steroid hormone production in human granulosa cells. In this study, we examined effects of GnRH on Ca2+ mobilization, protein kinase C activity and steroidogenesis of human granulosa cells. Human granulosa cells were harvested by aspiration of follicles during oocyte retrieval for IVF. Test substances, tha...

The gonadotropin-releasing hormone receptor (GnRH-R) of the African catfish couples to phospholipase C and belongs to the large family of G protein-coupled receptors. We recently demonstrated that removal of the carboxyl-terminal tail (S331-Q379) from the catfish GnRH-R results in a loss of agonist binding; the current study sought to define more precisely the role of this region in receptor fu...

routinely, a bolus of 5.000-10.000 iu human chorionic gonadotropin (hcg) is usedfor the final follicular maturation and ovulation as a standard method. hcg has thesame effect of luteinizing hormone (lh) with long half-life. it has the longlutheotrophic effect which increases the risk of ovarian hyper stimulation syndrome(ohss). recently, gonadotropin-releasing hormone agonist (gnrh-a) trigger h...

BACKGROUND The specific role of LH in folliculogenesis and oocyte maturation is unclear. GnRH antagonists, when administered in the late follicular phase, induce a sharp decrease in serum LH which may be detrimental for IVF outcome. This study was performed to evaluate whether the replacement of GnRH agonist (triptorelin) by a GnRH antagonist (ganirelix; NV Organon) in oocyte donation cycles ha...