[1] Forcing by absorbing atmospheric black carbon (BC) tends to heat the atmosphere, cool the surface, and reduce the surface latent and sensible heat fluxes. BC aerosol can have a large impact on regional climates and the hydrologic cycle. However, significant uncertainties remain concerning the increases in (1) the total amount of all aerosol species and (2) the amount of aerosol absorption t...

PURPOSE We determined whether polyethylenimine (PEI), a polycationic DNA carrier, can be used to deliver the interleukin (IL) 12 gene by aerosol to treat established osteosarcoma (OS) lung metastases in a nude mouse model. EXPERIMENTAL DESIGN Tumor response was assessed using our OS lung metastases model. Treatment with aerosolized PEI containing the murine IL-12 gene (PEI:IL-12; 600 microl P...

[1] Simulated aerosol fields from a coupled aerosol/atmospheric circulation model that includes prediction of both sulfate aerosol size and number are evaluated. Sensitivity tests are used to evaluate uncertainties due to the inclusion of primary emitted particulate sulfate as a means of representing nucleation of particles in subgrid-scale plumes, the use of two boundary layer aerosol nucleati...

43 The new level 3 aerosol profile data derived from the Cloud-Aerosol Lidar and 44 Infrared Pathfinder Satellite Observations (CALIPSO) provide multi-year global 45 aerosol distribution with high vertical resolution. We analyzed seasonal and diurnal 46 variations of the vertical distributions of aerosol properties represented by this 47 CALIPSO data for the period of five years. Results show t...

BACKGROUND There is an urgent need for an improved understanding of the sources, distributions and properties of atmospheric aerosol in order to control the atmospheric pollution over northeastern Himalayas where rising anthropogenic interferences from rapid urbanization and development is becoming an increasing concern. METHODOLOGY/PRINCIPAL FINDINGS An extensive aerosol sampling program was...

Given significant challenges with available measurements of aerosol acidity, proxy methods are frequently used to estimate the acidity of atmospheric particles. In this study, four of the most common aerosol acidity proxies are evaluated and compared: (1) the ion balance method, (2) the molar ratio method, (3) thermodynamic equilibrium models, and (4) the phase partitioning of ammonia. All meth...

Output from jet nebulisers is calibrated traditionally by weighing them before and after nebulisation, but the assumption that the weight difference is a close measure of aerosol generation could be invalidated by the concomitant process of evaporation. A method has been developed for measuring aerosol output directly by using a solute (fluoride) tracer and aerosol impaction, and this has been ...

The IPCC has stressed the importance of producing unbiased estimates of the uncertainty in indirect aerosol forcing, in order to give policy makers as well as research managers an understanding of the most important aspects of climate change that require refinement. In this study, we use 3-D meteorological fields together with a radiative 5 transfer model to examine the spatially-resolved uncer...

We investigated the large-scale connection between African aerosol and precipitation in the West African Monsoon (WAM) region using 8-year (2000–2007) monthly and daily Moderate Resolution Imaging Spectroradiometer (MODIS) aerosol products (aerosol optical depth, fine mode fraction) and Tropical Rainfall Measuring Mission (TRMM) precipitation and rain type. These high-quality data further confi...

BACKGROUND To prepare for a possible influenza pandemic, a better understanding of the potential for the airborne transmission of influenza from person to person is needed. OBJECTIVES The objective of this study was to directly compare the generation of aerosol particles containing viable influenza virus during coughs and exhalations. METHODS Sixty-one adult volunteer outpatients with influ...