The endocannabinoid system plays an important role in numerous physiological processes including mood, appetite, and pain sensation. A critical compound in maintaining cannabinoid tone is the endocannabinoid anandamide (AEA). We have recently shown that AEA is metabolized by several different human cytochromes P450 (P450) to form a number of metabolites, one of which exhibits increased biologic...

Adrenal epithelioidangiosarcoma (AEA) is a rare neoplasm that accounts for less than 1% of sarcomas. Due to its rarity, it can easily be misdiagnosed, both by the clinician and the pathologist. Data on the patient's occupational history was collected and analyzed. The bibliographic data was found on the PUBMED bibliographic search site after entering the word "extrahepaticangiosarcoma". We repo...

BACKGROUND Environmental conditions in early life can induce permanent physiological changes, sometimes increasing the risk of chronic diseases during adulthood. Neural and peripheral circuits controlling energy balance may be modulated during such a critical period. Since type 1 cannabinoid receptors (CB1R) have recently emerged as targets for modulating energy balance, their premature chronic...

The chemical similarity between some synthetic agonists of vanilloid receptors, such as olvanil (N-vanillyl-cis-9-octadecenoamide), and the 'endocannabinoid' anandamide (arachidonoyl-ethanolamide, AEA), suggests possible interactions between the cannabinoid and vanilloid signalling systems. Here we report that olvanil is a stable and potent inhibitor of AEA facilitated transport into rat basoph...

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The endocannabinoid system regulates cell proliferation and migration in human breast cancer cells. In this study, we showed that a metabolically stable analog of anandamide, 2-methyl-2'-F-anandamide (Met-F-AEA), inhibited the RHOA activity and caused a RHOA delocalization from the cell membrane to cytosol determining a decrease in actin stress fibers. Overexpression of a dominant negative of R...

A major advance in the field of cannabinoid research was the discovery of the endocannabinoid system, which is currently thought to consist of two G proteincoupled receptors (cannabinoid CB1 and CB2 receptors) and endogenous compounds such as arachidonoylethanolamide (i.e., anandamide; AEA; Fig. 1) and 2-arachidonoyl glycerol (2-AG) that can activate these receptors and are known as endocannabi...

El presente texto expone el contexto y las condiciones que dieron origen a la creación del Archivo Etnográfico Audiovisual (AEA) en Instituto Nacional Indigenista (INI), hoy de los Pueblos Indígenas (INPI), con objetivo reconocer discursos configuran impulso generar coleccionar imágenes etnográficas. análisis indaga sobre qué le da característica archivo al AEA cuáles son plantear rescate cultu...