abstract background: pressure ulcer is one of the main concerns of nurses in medical centers around the world, which, if untreated, causes irreparable problems for patients. in recent years, nitric oxide (no) has been proposed as an effective method for wound healing. this study was conducted to determine the effect of nitric oxide on pressure ulcer healing. materials and methods: in this clini...

High-mobility group box 1 (HMGB1) was initially discovered as a nuclear protein that interacts with DNA as a chromatin-associated non-histone protein to stabilize nucleosomes and to regulate the transcription of many genes in the nucleus. Once leaked or actively secreted into the extracellular environment, HMGB1 activates inflammatory pathways by stimulating multiple receptors, including Toll-l...

Small, early cancers are sometimes diagnosed serendipitously following the removal of anal tags. More advanced lesions present as a mass, non-healing ulcers, pain, rectal bleeding, itching, discharge and faecal incontinence. A relevant history to elicit symptoms and predisposing factors should be documented. Proctoscopy and examination under anaesthesia facilitates biopsy. Diagnosis requires hi...

Advanced practice nurses provide expert clinical care for patients and families experiencing chronic and terminal illnesses. However, there is no theoretical framework that guides praxis in palliative care. This article describes a unitary-caring model that transforms national standards of palliative care into a values-based praxis focused on healing and caring.

This previously unreported Renaissance painting depicts a young woman with locally advanced breast cancer reaching out towards a healing potion in the church of Santa Maria della Grazia in Milan, that houses Leonardo da Vinci's Last supper. Today's potion may well contain neoadjuvant systemic therapy including trastuzumab that may allow breast conserving surgery and targeted intraoperative radi...

Objective- To evaluate the role of greater omentum incorporation of coral in healing of the long bone defect in dog model. Design- Experimental in-vivo study. Animals- Sixteen adult mongrel male dogs weighing 26.2±2.5 kg, free of evident infectious or parasitic illnesses were used in this study. Procedures- The operative procedure was undertaken under general anesthesia. Radial bone was expo...

background: coronally advanced fl ap (caf) has been shown to effectively treat gingival recession. platelet rich plasma (prp), containing autologous growth factors, has been shown to promote soft tissue healing. the aim of this clinical study was to determine whether the addition of an autologous prp to a caf when compared to a caf alone would improve the clinical outcome for treatment of multi...

Advances in Wound Repair is an updated collection of advanced technology in wound repair based on the author’s personal experience and a unique contribution to the literature on wound repair. It is ideally suited for plastic surgeons, wound specialists, and other healthcare professionals who have a particular interest in, or wish to develop greater knowledge of, wound repair. Professor Seung-Ky...

Randomized controlled trials in wound care generalize poorly because they exclude patients with significant comorbid conditions. Research using real-world wound care patients is hindered by lack of validated methods to stratify patients according to severity of underlying illnesses. We developed a comprehensive stratification system for patients with wounds that predicts healing likelihood. Com...