Abstract The aim of the current study was to evaluate therapeutic potentials Hydroxyquinoline Sulfanilamide (HSM) for Alzheimer’s disease in a mice model Streptozotocin (STZ)-induced diabetes. antioxidant analysis brain homogenates carried out by catalase (CAT) assay, reduced glutathione (GSH) and lipid peroxidation (LPO) assay. Biochemical blood plasma conducted peroxidase (POD) assay superoxi...

Drug dependence is a major health problem in adults and has been recognized as a significant problem in adolescents. We previously demonstrated that repeated treatment with a behaviorally sensitizing dose of ethanol in adult mice induced tolerance or no sensitization in adolescents and that repeated ethanol-treated adolescents expressed lower Fos and Egr-1 expression than adult mice in the pref...

Abstract The current work examined the therapeutic potential of 6-aminoflavone (6AF) against mouse model-based oxidative stress-driven synaptic and memory impairment caused by lipopolysaccharides (LPSs). In brains experimental mice, LPS administration for 3 weeks significantly increased stress inhibiting antioxidant enzymes, including superoxide dismutase, peroxidase, catalase, glutathione, upr...

A single i.p. injection of butylated hydroxytoluene (BHT) 6 h before a single urethan injection had varying effects on lung tumorigenesis in mice of different strains and ages. Strains exhibiting both high (A/J, SWR/J) and low (BALB/cByJ, 129/J, CS7BL/6J) susceptibility to urethan tumorigenesis were tested in this study. BHT treatment decreased tumor multiplicity by an average of 32% in adult A...

Nitric oxide is involved in development and postnatal adaptation of the pulmonary circulation. This study aimed to determine whether genetic deletion of nitric oxide synthase (NOS) would lead to maldevelopment of the pulmonary arteries in fetal life, compromise adaptation to extrauterine life, and be associated with a pulmonary hypertensive phenotype in adult life and if any abnormalities were ...

objective: the aim of this study was to investigate the effects of curcumin on epididymal sperm parameters in adult male navel medical research institute (nmri) mice exposed to sodium arsenite. materials and methods: in this experimental study, we divided the animals into four groups: control, sodium arsenite (5 mg/kg), curcumin (100 mg/kg) and curcumin+sodium arsenite. exposures were performed...

The subgranular zone (SGZ) of hippocampal dentate gyrus (HDG) is a primary site of adult neurogenesis. Toll-like receptors (TLRs), are involved in neural system development of Drosophila and innate immune response of mammals. TLR2 is expressed abundantly in neurogenic niches such as adult mammalian hippocampus. It regulates adult hippocampal neurogenesis. However, the role of TLR2 in adult neur...

background: acrylamide (aa) is an important industrial chemical primarily. aa is also found in carbohydrate-rich foods that are prepared at high temperatures, such as french fries and potato chips. it is demonstrated that aa is a carcinogen and reproductive toxin and has ability to induce sperm damage. objective: the aim of this study was to observe the effects of aa on sperm parameters and eva...

the ability to maintain and study human tissues in in-vivo environment has proved to be a valuable tool in breast cancer research for several decades. the most widely tissues have been xenografts established human breast cancer cell lines into athymic nude mice. the aim of this study was to provide a new accurate and affordable method for the establishment of breast cancer xenograftin nude mice...