Young adult and aged F344 rats were compared on a silent gap variant of the prepulse inhibition paradigm. Animals were tested using a 50-ms single tone cue, followed by 8 days of silent gap testing. The first 3 days of gap testing were long gaps (range 2 to 100 ms) followed by 5 days of short gaps (range 2 to 10 ms). The effects of gap length, prior experience, and age, on the magnitude and dir...

Triple antimalarial combination therapies may overcome the emergence of drug resistance. Sulfadoxine/pyrimethamine (S/P) is an drug. Clindamycin (C) has potential antiplasmodial effect. This study assessed whether activity S/P can be augmented by C on Plasmodium berghei-infected mice. Adult Swiss albino mice (25-30g) were grouped and infected with berghei. The orally treated daily (21.4/10.7 mg...

Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic using four Yamanaka transcription factors. Since their discovery, cell (SC) field achieved significant milestones and opened several gateways in area disease modeling, drug regenerative medicine. In parallel, emergence clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (...

Activated in response to chemotherapy, senescence is a tumor suppressive mechanism that induces a permanent loss of proliferation. However, in response to treatment, it is not really known how cells can escape senescence and how irreversible or incomplete this pathway is. We have recently described that cells that escape senescence are more transformed than non-treated parental cells, they resi...

Auditory neurons in the superior colliculus (SC) respond preferentially to sounds from restricted directions to form a map of auditory space. The development of this representation is shaped by sensory experience, but little is known about the relative contribution of peripheral and central factors to the emergence of adult responses. By recording from the SC of anesthetized ferrets at differen...

The location of midgut bacteria relative to meconial peritrophic membranes (MPMs) and changes in bacterial numbers during midgut metamorphosis were studied in Anopheles punctipennis (Say), Culex pipiens (L.), and Aedes aegypti (L.) pupae and newly emerged adults. After adult emergence in Aedes, Anopheles, and most Culex, there were few to no bacteria in the midgut. In most newly emerged adult m...

Runx1 controls hematopoietic stem cell emergence and hair follicle stem cell (HFSC) activation and proliferation in adult skin. Here we use lineage tracing and mouse genetic manipulation to address the role of Runx1 in the embryonic development of HFSCs. We find Runx1 is expressed in distinct classes of embryonic skin precursors for short-term HF progenitors, adult HFSCs, and mesenchymal progen...

Vigilance by California ground squirrels (Spermophilus beecheyi) following two kinds of naturally occurring "alarm" calls was examined. Chatters were usually singly emitted calls while repetitive calls were initiated by one or more chatters and continued with a variable, but long, series of "chats." During noncalling periods adults tended to be more vigilant than were pups (young of the year); ...

Populations of Homalodisca coagulata (Say) were sampled from citrus orchards in southern California, USA to characterize and quantify seasonal occurrences of nymphs and adults with the goal of identifying management opportunities through well-timed treatments and/or natural enemy releases. Higher densities of H. coagulata in 2001 contributed to a complete seasonal profile that began in early sp...

In this study, the activity of cyromazine was evaluated following WHO standard procedures against susceptible and resistant mosquito strains of Anopheles gambiae, Culex quinquefasciatus, and Aedes aegypti. The dose for 50% and 90% inhibition of adult emergence (IE50 and IE90) ranged from 0.028 mg/liter to 0.17 mg/liter and from 0.075 mg/liter to 0.42 mg/liter, respectively. The effects of cyrom...