The condition’s pathophysiology is to be traced in by far the largest share of cases (85%) to an aldosterone-producing adrenocortical adenoma, most often solitary and unilateral rather than multiple of bilateral. The syndrome may be accompanied also by cortical hyperplasia without nodules or at times with diffuse micronodules, or by carcinoma. Onset varies according to published series, ranging...

The clinical case of a 65-year-old woman with an incidentally detected left-sided mass in the upper renal pole is presented. A functional adrenal tumor was excluded. The mass was removed retroperitoneoscopically. The perioperative period was uneventful. The histopathological examination revealed a heterotopic intrarenal adrenocortical oncocytoma. Adrenal oncocytic neoplasms are very rare, with,...

We studied a patient with food-induced, ACTH-independent, Cushing's syndrome and a unilateral adrenocortical adenoma. In vivo cortisol secretion was stimulated by mixed, glucidic, lipidic, or proteic meals. Plasma ACTH levels were undetectable, but iv injection of ACTH stimulated cortisol secretion. Unilateral adrenalectomy was followed by hypocortisolism with loss of steroidogenic responses to...

The steroidogenic activities in non-hyperfunctioning adrenal adenoma (NHFA) have not yet been fully examined. Steroid content both in adenoma and its non-tumorous adjacent adrenal tissue was measured by the HPLC system in 8 cases of NHFA and 2 cases of preclinical Cushing's syndrome (PCS). Activities of cytochrome P450c17ct, P450c21, P450c11 fl, P450c18 and aldosterone-synthesizing enzyme (P450...

A right adrenal tumor was found incidentally during abdominal computed tomography exam in a 51-year-old female patient, who had had diabetes and hypertension for more than 10 years. The computed tomography scan was arranged for possible pancreatic lesion by a neurologist. Norepinephrine level was high in the plasma and urine. Vanillylmandelic acid level was elevated in the urine. Diurnal cortis...

To the Editor: A 66‐year‐old male was seen in the outpatient clinics of Beijing Friendship Hospital with the complaint of right flank pain for the past 5 months. Computed tomography (CT) revealed the presence of adrenal masses [Figure 1a]. Serum norepinephrine, epinephrine, and dopamine levels were normal, while cortisol, renin, and angiotensin levels were elevated. He was then admitted to the ...

Because of the more widespread and frequent use of cross-sectional techniques, mainly computed tomography (CT), an increasing number of adrenal tumors are detected as incidental findings ("incidentalomas"). These incidentaloma patients are much more frequent than those undergoing imaging because of symptoms related to adrenal disease. CT and magnetic resonance imaging (MRI) are in most patients...