PURPOSE Determine whether Compound 49b treatment ameliorates retinal changes due to the lack of β2-adrenergic receptor signaling. METHODS Using retinas from 3-month-old β2-adrenergic receptor-deficient mice, we treated mice with our novel β1-/β2-adrenergic receptor agonist, Compound 49b, to assess the effects of adrenergic agonists acting only on β1-adrenergic receptors due to the absence of ...

Cardiac myocytes endogenously express α and β adrenergic receptors, prototypes of the G-protein coupled receptor superfamily. Depending upon the dose of norepinephrine (agonist) exposure, hypertrophy and apoptosis are initiated by differential induction of two discrete constituents of the transcription factor AP-1, i.e., FosB and Fra-1. We explored differential adrenergic signaling as a paradig...

In mammals, the roles of liver and skeletal muscle glycogen in adrenaline-induced hyperglycaemia are well known. However, amphibians, there is limited information on relative contribution hyperglycaemia. This study investigated effects adrenaline blood glucose, plasma lactate, liverand role adrenergic receptors common African toad, bufo regularis. One hundred twenty-five adult toads (70-100g) b...

Objective: Valeriana (V) wallichii DC is found among the ground flora of Himalayan regions and used as herbal medicine for CNS disorders in Indian systems medicine. In study, aimed to investigation involvement neuro-chemical-systems V. induced antidepressant effects mice.
 Methods: The activity aqueous alcoholic extracts was measured by using Forced Swim Test Tail Suspension mice, whereas ...

C ongestive heart failure is associated with pronounced alterations in adrenergic nervous system function. Levels of myocardial norepinephrine are decreased, as first reported in 1963,1 a phenomenon later found to be associated with increased sympathetic nervous system activation and high levels of circulating plasma catecholamines2 in combination with abnormalities in neural reuptake of norepi...

Clonidine (Catapres, Catapresan), guanfacine (Estulic), and methyldopa (Aldomet) are the prototypes of centrally acting antihypertensive drugs. Clonidine and guanfacine are lipophilic drugs that readily penetrate into the brain, where they stimulate alpha-adrenergic receptors in the pontomedullary region. The stimulation of these central alpha-adrenergic receptors has been shown to activate an ...

The nature of beta adrenergic receptors in human cerebral arteries was characterized and alteration of these receptors after subarachnoid hemorrhage was examined using a radioligand binding assay. The specific 3H-dihydroalprenolol, a beta adrenergic antagonist, binding to human cerebral arteries was saturable and of high affinity (KD = 12.3 nM) with a Bmax of 790 fmol/mg protein. Ki values and ...