α(1)-Adrenergic receptor subtypes are widely distributed in the central nervous system and are involved in autonomic functions such as micturition. We investigated the presence and the role of supraspinal and/or spinal α(1)-adrenergic receptors in modulating the micturition reflex in conscious female Wistar rats. The expression of α(1)-adrenergic receptor subtypes in rat brain and lumbosacral s...

The threshold sensitivity of cardiovascular tissues to alpha-adrenergic stimulation is determined largely by the affinity of alpha-adrenergic receptors for agonists. To determine whether changes in alpha-adrenergic receptor affinity could contribute to the regulation of cardiac and vascular responsiveness, we used the alpha-adrenergic-selective radioligands, [3H]prazosin, [3H]-WB-4101, and [3H]...

Adrenergic receptor β3 (ADRβ3) is a member of the rhodopsin-like G protein-coupled family. The binding ligand to ADRβ3 activates adenylate cyclase and increases cAMP in cells. highly expressed white brown adipocytes controls key regulatory pathways lipid metabolism. Trp64Arg (W64R) polymorphism associated with early development type 2 diabetes mellitus, lower resting metabolic rate, abdominal o...

Chlamydia lung infection caused by trachomatis is a serious particularly in infants but there are few studies about infection. Chlamydial genital and infections mice frequently done with muridarum. The purpose of our study was to explore the effect stress chlamydia male mice. We hypothesize that changes level cytokine production monocytes during As result from these include counting live cells,...

The goal of this study was to test the hypothesis that circulating catecholamines are primarily responsible for alpha-adrenergic coronary vasoconstriction during submaximal exercise. The experimental series consisted of chronic studies in which a regional left ventricular sympathectomy was performed with phenol. Myocardial perfusion to the innervated and sympathectomized left ventricular region...

The threshold sensitivity of cardiovascular tissues to a-adrenergic stimulation is determined largely by the affinity of a-adrenergic receptors for agonists. To determine whether changes in a-adrenergic receptor affinity could contribute to the regulation of cardiac and vascular responsiveness, we used the a-adrenergic-selective radioligands, [H]prazosin, [H]-WB-4101, and [H]rauwalscine, to stu...

Ocular tension of cats was measured after topical administration of the selective beta 1-adrenergic agonist CGP 7760B, the selective beta 1-adrenergic antagonist atenolol, the selective beta 2-adrenergic agonist salbutamol, the selective beta 2-adrenergic antagonist H 35/25, and the mixed beta 1- and beta 2-adrenergic antagonist timolol. Although atenolol did not alter intraocular pressure, CGP...

Increased sympathoadrenal activity appears to play an important role in the development or maintenance of elevated blood pressure in hypertensive patients and various animal models of hypertension. Alterations of adrenergic receptor number or responsiveness might contribute to this increased activity. We therefore reviewed the data on adrenergic receptor alterations in hypertension with special...

AGAP2 [Arf (ADP-ribosylation factor) GAP (GTPase-activating protein) with GTP-binding-protein-like, ankyrin repeat and PH (pleckstrin homology) domains] is a multidomain Arf GAP that was shown to promote the fast recycling of transferrin receptors. In the present study we tested the hypothesis that AGAP2 regulates the trafficking of β2-adrenergic receptors. We found that AGAP2 formed a complex ...

OBJECTIVE: VIP and PACAP, two structurally related peptides, stimulate c AMP, steroidogenesis and progesterone (PROG) release from cultured rat granulosa cells. VIP and PACAP38 are known to mimic the effects of β-adrenergic receptor stimulation in the rat pinealocytes causing an increased melatonin synthesis. These effects were markedly potentiated by α1 adrenergic receptor stimulation. METHODS...