In-silico Computer-Aided Drug Design (CADD) significantly relies on cybernetic screening of Plant Based Natural Products (PBNPs) as a prime source bioactive compounds/ drug leads due to their unique chemical structural scaffolds and distinct functional characteristic features amenable design development. In the Post-COVID-Era large number publications have focused PBNPs. Moreover, PBNPs still r...

The urgent need of neuraminidase inhibitors (NI) has provided an impetus for understanding the structure requisite at molecular level. Our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. The main objective of present study is to develop selective NI, with least toxicity and dru...

the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...

The urgent need of neuraminidase inhibitors (NI) has provided an impetus for understanding the structure requisite at molecular level. Our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. The main objective of present study is to develop selective NI, with least toxicity and dru...

Sirtuins family are a Nicotinamide Adenine Dinucleotide (NAD+) dependent histone deacetylase enzyme. have been implicated in the pathogenesis of various diseases including cancer, neurological disorders and metabolic syndromes, hence sirtuins appointed as promising therapeutic target for diseases, by regulating its activity small molecules modulators. The indole containing selisistat (EX-527) d...

A member of the Iridoviridae family has been detected as erythrocytic necrosis virus (ENV), which causes viral (VEN) in 20 marine and anadromous fishes. The major capsid protein (MCP) is main structural iridoviruses responsible for causing disease various It found that VEN utilizes to enter into host cell blocking entry by targeting can reduce economic losses caused pathogen. objective study wa...

Keganasan pada pankreas diakibatkan karena tidak terkendalinya proliferasi sel yang akan mengarahpada berkurangnya proses apoptosis sel. Oleh itu, salah satu usaha untuk menangani kasuskanker ini adalah dengan menghambat protein antiapoptosis seperti AKT kinase. Inhibisiprotein kinase didasarkan mekanisme penghambatan fosforilasi padasel pankreas. Senyawa golongan xanton dari buah manggis (Garc...