‘Health utilities’ measure patient preferences for perfect health compared to specific unhealthy states, such as asthma, a fractured hip, or colon cancer. When integrated over time, these estimations are called quality adjusted life years (QALYs). Until now, characterizing health utilities (HUs) required detailed patient interviews or written surveys. While reliable and specific, this data rema...

BACKGROUND Third-generation aromatase inhibitors are being considered as an alternative to tamoxifen as first-line therapy for advanced breast cancer. These newer therapies are more expensive, and will gain greater acceptance if they can demonstrate cost-effectiveness. METHODS Life table analyses are used to compare the costs and benefits [life years gained and quality-adjusted life years (QA...

OBJECTIVE To present a long-term policy model of cardiovascular disease (CVD) in moderate-to-advanced chronic kidney disease (CKD). METHODS A Markov model with transitions between CKD stages (3B, 4, 5, on dialysis, with kidney transplant) and cardiovascular events (major atherosclerotic events, haemorrhagic stroke, vascular death) was developed with individualised CKD and CVD risks estimated ...

BACKGROUND To estimate life years and quality-adjusted life years (QALYs) lost and the economic burden of aneurysmal subarachnoid haemorrhage (aSAH) in the United Kingdom including healthcare and non-healthcare costs from a societal perspective. METHODS All UK residents in 2005 with aSAH (International Classification of Diseases 10th revision (ICD-10) code I60). Sex and age-specific abridged ...

BACKGROUND Artificial bowel sphincter (ABS) and dynamic graciloplasty (DG) are surgical treatments for faecal incontinence (FI). FI may affect quality of life (QOL) so severely that patients are often willing to consider a permanent end stoma (ES). It is unclear which is the more cost-effective strategy. METHOD Probability estimates for patients with FI were obtained from published data (ABS,...

BACKGROUND Traffic injuries can cause physical, psychological, and economical impairment, and affected individuals may also experience shortcomings in their post-accident care and treatment. In an earlier randomised controlled study of nursing intervention via telephone follow-up, self-ratings of health-related quality of life were generally higher in the intervention group than in the control ...

OBJECTIVES To examine the cost-effectiveness of primary debulking surgery (PDS) when compared to neoadjuvant chemotherapy (NACT) in the management of epithelial ovarian cancer (EOC) using Surveillance, Epidemiology, and End Results data linked to Medicare claims (SEER-Medicare). METHODS Using a Markov model, the cost-effectiveness of PDS was compared to that of NACT. We modeled cost and survi...

We write in response to a recent discussion Value Health over the preference weights for EQ-5D-5L.1Norman R. Olsen J. Competing views on EQ-5D-5L valuation set.Value Health. 2020; 23: 574-575Abstract Full Text PDF PubMed Scopus (4) Google Scholar It would appear that there is disagreement and options open move from EQ-5D-3L value framework support reference case lifetime models NICE assessment....

BACKGROUND Tetralogy of Fallot is a congenital heart disease that requires surgical repair without which survival through childhood is extremely rare. The aim of this paper is to use data from the mandatory follow-up of patients with Tetralogy of Fallot to model the health-related costs and outcomes over the first 55-years of life. METHOD A decision analytical model was developed to establish...