Until recently, it has been impossible to determine which patients with resected stage I lung cancer are among the 30% who will die of metastatic cancer within 5 years of surgery. Bioinformatics tools applied to lung cancer expression profiling data have identified prognostic genes that have been used to develop predictor models, but thus far, these models have not been incorporated into routin...

background gastric cancer is the second most common cause of cancer death worldwide. lentinan was shown to induce apoptosis in gastric cancer cells and could be used for the treatment of gastric cancer. objectives in this study, we analyzed anticancer effect of lentinan, a fungal β-glucan, on the gastric adenocarcinoma cell line (ags). materials and methods we used the dna ladder and tunnel app...

In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives were synthesized and tested for their antitumor activities in vitro against panel four human cancer cell lines DNA-binding affinity. Among compounds, 4c 5b with 4-substitution at phenyl ring found to have highest inhibitory effects breast adenocarcinoma (MCF-7), colon (HCT-116), hepatocellular carcinoma (HePG-2), skin ...

Esophageal cancers are among the most prevalent malignancies worldwide, with high rates of incidence and mortality (Ferlay et al., 2010; Spechler et al., 2011). There are two major histological types of esophageal carcinoma: esophageal squamous cell carcinoma (ESCC) and adenocarcinoma with considerably varied epidemiological features. ESCC continues to be the major type of esophageal cancer in ...

cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. the identification of new cytotoxic drugs with low side effects on immune system has developed as important area in new studies of immunopharmacology. thymoquinone (tq), derived from the medicinal spice nigella sativa (also called black cumin) ex...

Mucin 1 (MUC1) is a diagnostic factor and therapy target in lung adenocarcinoma. MUC1 C-terminal intracellular domain (CD) interacts with estrogen receptor (ER) a and increases gene transcription in breast cancer cells. Because lung adenocarcinoma cells express functional ERa and ERb, we examined MUC1 expression and MUC1–ER interaction. Because blocking MUC1 CD with an inhibitory peptide (PMIP)...

Background: Norepinephrine plays a trophic role in the control of cell replication and differentiation in target cells that express adrenergic receptors. Methods: In this study, we have tested the influence of infraphysiological, physiological and supraphysiological concentrations (0.0001 nM, 1 nM, 10000 nM) of human norepinephrine on the proliferation of breast cancer cells (human breast adeno...

Further investigations on phytochemical constituents of dichloromethane extract fromroots of Salvia lachnocalyx (S. lachnocalyx) led to the isolation and identification of eightknown diterpenoids from this plant for the first time. The chemical structures of the purifiedcompounds were elucidated using spectroscopic analyses including EI-MS, 1H and 13C NMR andby compariso...

OBJECTIVE We describe the case of a patient with metastatic breast cancer who presented with eyelid margin thickening and madarosis more suggestive of sebaceous cell carcinoma than metastatic disease. Histopathology confirmed metastatic breast adenocarcinoma. CASE REPORT A 59-year-old woman with a known history of metastatic breast carcinoma actively enrolled in a clinical trial presented wit...