In this review, we highlight the role of neuroimaging techniques in studying the emotional and cognitive-behavioral components of the addiction syndrome by focusing on the neural substrates subserving them. The phenomenology of drug addiction can be characterized by a recurrent pattern of subjective experiences that includes drug intoxication, craving, bingeing, and withdrawal with the cycle cu...

The study of drug addiction integrates a broad range of research fields including social sciences, psychology, psychiatry, behavioural neurosciences, pharmacology or genetics, each of which being represented in the different chapters of this book. Preclinical studies involving behaving animals have been pivotal for our increasing insights into the psychobiological substrates of addiction and so...

Background Behavioral addiction research has been particularly flourishing over the last two decades. However, recent publications have suggested that nearly all daily life activities might lead to a genuine addiction. Methods and aim In this article, we discuss how the use of atheoretical and confirmatory research approaches may result in the identification of an unlimited list of "new" behavi...

The cellular activity of norrisolide (7), a novel Golgi-vesiculating agent, was dissected as function of its chemical structure. This natural product induces irreversible vesiculation of the Golgi membranes and blocks protein transport at the level of the Golgi. The Golgi localization and fragmentation effects of 7 depend on the presence of the perhydroindane core, while the irreversibility of ...

Oncogene addiction is an intriguing new term that has emerged in the lexicon of cancer biology (1). This term implies that tumor cells may have an extraordinary, almost complete dependence on the function of one or more genes (oncogenes) for their survival, whereas these same genes expressed in normal cells are not absolutely essential. The human epidermal growth factor receptor type 2 (HER2) i...

B. Bie,1 H. L. Fields,2 J. T. Williams,3 and Z. Z. Pan1 1Departments of Symptom Research and Biochemistry and Molecular Biology, University of Texas–M. D. Anderson Cancer Center, Houston, Texas 77030, 2Departments of Neurology and Physiology and the Wheeler Center for the Neurobiology of Addiction, University of California San Francisco, San Francisco, California 94143, and 3Vollum Institute, O...

Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6, PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8, and Departments of Chemistry and Chemical Biology, and Medical Physics and Applied Radiation Sciences, McMaster University, 1280 Main St...

Xiaoli Hu, Huihui Guo, Yan He, Shan Wang, Lingling Zhang, Shi Wang, Xiaoting Huang, Scott William Roy, Wei Lu, Jingjie Hu* and Zhenmin Bao Key Laboratory of Marine Genetics and Breeding (Ocean University of China), Ministry of Education, Qingdao 266003, China Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA Depa...