A synthetic approach to the modification of drug Riluzole with pharmacologically active fragments (adamantane, carbazole, tetrahydrocarbazole, γ-carboline, and phenothiazine) was proposed, which is based on copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition azide-containing pharmacophores alkyne-containing derivatives Riluzole.

2014 The ODIC phase of adamantane (208 K-541 K) was studied by Raman light scattering between 209 K and 500 K. The 1 220 cm-1, E symmetry, vibrational line was recorded with Eg and F2g symmetries. The Eg spectra, due to ordered molecules, are broadened by a residence time effect. The F2g spectra, which correspond to molecules as they rotate, could be attributed to the modification of the intern...

In the title compound, C(25)H(30)O, the adamantane cage consists of three fused cyclo-hexane rings in classical chair conformations, with C-C-C angles in the range 107.15 (9)-111.55 (9)°. The dihedral angle between the benzene rings is 46.91 (4)° and the conformation is stabilized by a weak intra-molecular C-H⋯π inter-action.

In the title compound, C(32)H(24)F(4)N(2)O, all four six-membered rings that constitute the diaza-adamantanone cage adopt chair conformations. Two of the four fluoro-phenyl substituents occupy axial positions and the other two occupy equatorial positions relative to their respective C(5)N rings of the adamantane framework. The crystal structure is stabilized by C-H⋯O inter-actions, generating a...

The title compound, C(18)H(23)NO(3), the adamantane derivative of norcantharidin, which is itself derived from cantharidin, crystallized with three independent mol-ecules in the asymmetric unit. In the crystal, mol-ecules are linked by inter-molecular C-H⋯O inter-actions, leading to the formation of a supra-molecular two-dimensional network.

Pd-catalyzed amination of isomeric 2,6-, 2,8-, 4,8- and 4,7-dichloroquinolines was studied using adamantane-containing amines in which substituents at the nitrogen atom differ in bulkiness. The selectivity of the amination of 2,6-dichloroquinoline was very low, substantially better results were obtained with 2,8-dichloroquinoline, and 4,8- and 4,7-dichloroquinolines provided the best yields of...

Tripodal molecules consisting of a tetrasubstituted adamantane with three phenylacetylene legs and a reversibly photoswitching apex were designed as "single molecular tips" for both chemical and topographical characterization of the substrate surface. By covalent attachment onto gold-coated AFM tips through three S-Au bonds, these rigid tripodal molecules are expected to act as sharp, robust, a...