The acute phase protein response is a well-described generalized early host response to tissue injury, inflammation and infection, observed as pronounced changes in the concentrations of a number of circulating serum proteins. The biological function of this response and its interplay with other parts of innate host defence reactions remain somewhat elusive. In order to gain new insight into th...

Adult mouse hepatocytes respond in vivo to experimentally induced acute inflammation by an increased synthesis and secretion of alpha 1-acid glycoprotein, haptoglobin, hemopexin, and serum amyloid A. Concurrently, the production of albumin and apolipoprotein A-1 is reduced. To define possible mediators of this response and to study their action in tissue culture, we established primary cultures...

A nephelometric assay of concanavalin-A binding of serum acute phase proteins (con-A binding) has been used in cross-sectional and sequential studies of disease activity in rheumatoid arthritis (RA). Con-A binding correlated well with blood viscosity, C-reactive protein, and other individual acute phase reactants in patients with active RA. Twenty-four patients were treated for 6 months with D-...

Serum concentrations of fucose, sialic acid, and eight acute phase proteins were measured in single specimens from patients with cancer in order to determine whether the raised concentrations of protein bound sugars commonly found in cancer correlate with increased concentrations of the acute phase proteins. Strong positive correlations were found only with alpha 1-acid glycoprotein, alpha 1-an...

the purpose of this study was to evaluate the changes in the serum concentrations of haptoglobin (hp), serum amyloid a (saa) and igg, iga in calves with diarrhea caused by rotavirus, coronavirus, escherichia coli f5 and eimeria species. the experiment was carried out on 40 diarrhoeic and 10 non-diarrhoeic calves (group c). a total of 13 calves were infected with rotavirus or coronavirus (group ...

The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of...

background: recurrent herpes labialis (rhl) is one of most common infective vesiculoulcerative lesions. according to some studies administration of topical and/or systemic zinc compositions has been effective in treatment and prevention. this article aims to comparison of zinc level in healthy subjects and rhl patients in acute and convalescent phases. materials and methods: this was a retrospe...

Ischemic stroke has been classified as a merely thrombotic disease, so the main goal of its treatment is the recanalization of the occluded vasculature. However, despite fast restoration of blood circulation, progressive stroke still develops in many patients, which has led to the concept of reperfusion injury.  The underlying mechanism is only partly known. Though, it is accepted now, tha...

AJis'rRAcT. The changes in serum act,ivity of Lnterleukin (IL)-1, IL-6, and tumor necrosis factor (TNF) were studied in dogs with acute infiammation. Dogs with loea] jnfiammation induced by an intramuseular injection ef turpentinc oil showed clinically a typica} progression in the infiammatory rcsponse, recoveTing on day 14 after the treatment. Serum concentrations of C-reactive protein (CRP) a...