Background Acute necrotizing encephalopathy (ANE) is a devastating neurologic condition that can arise following variety of systemic infections, including influenza and SARS-Cov-2. The clinical features COVID-19-associated ANE in pediatric patients based on multi-case data have not yet been described remain obscure. We reviewed 12 to better describe the with COVID-19. Methods retrospectively co...

BACKGROUND Mammalian orthoreoviruses (MRVs) have a wide geographic distribution and can infect virtually all mammals. Infections in humans may be either symptomatic or asymptomatic. This study describes the isolation and identification of a natural reassortant MRV from least horseshoe bats (Rhinolophus pusillu) in China, referred to as RpMRV-YN2012. METHODS AND RESULTS The RpMRV-YN2012 was ob...

The conventional neuropathological manifestation of canine distemper virus (CDV) infection is characterized by demyelinating encephalomyelitis. Other recognized non-conventional neuropathological manifestations of distemper include acute encephalopathy, acute encephalitis, polioencephalomalacia, inclusion body polioencephalitis, and old dog encephalitis. With the use of molecular techniques, CD...

Influenzal encephalitis is frequently treated with oral antivirals, including amantadine (Symmetrel) for influenza A (if susceptible), rimantadine (Flumadine) for influenza A (if susceptible), and oseltamivir (Tamiflu) for influenza A and B; corticosteroids and immune globulin have also been tried. However, none of these agents has been proven to be effective for influenzal encephalitis. A comb...

Necrotizing fasciitis is a part of a spectrum of necrotizing soft tissue infections that usually follow a surgical intervention or a chronic / acute medical illness. Diagnosis is often based on symptoms which classically start within hours after an injury. There are no reports on the use of PET/CT in this condition. Sparing reports of its association in patients with malignancy (Ca of colon and...

PURPOSE Acute necrotizing encephalopathy (ANE) is a fulminant disease of the brain characterized by bilateral thalamic lesions, and is prevalent among children in East Asia. The prognosis of ANE is usually poor with a high mortality rate and neurological sequelae. This study aimed to delineate the clinical characteristics and prognostic factors of ANE. METHODS We retrospectively analyzed clin...