Our findings demonstrate the pivotal importance of caspase-3 in regulating renal microvascular dysfunction, fibrogenesis, and long-term impairment after acute kidney injury induced by ischemia-reperfusion injury. Furthermore, this study establishes predominant role peritubular capillary integrity as a major contributor to progressive dysfunction

BACKGROUND Acute kidney injury is a common complication of liver transplantation. In this single-centre retrospective observational study, we investigated the impact of acute kidney disease on liver recipient survival. METHODS The study population consisted of patients who underwent a liver engraftment between January 2002 and November 2006, at a single transplantation centre in São Paulo, Br...

Background: Patients who undergo major orthopedic surgery are at risk of acute kidney injury (AKI) due to blood loss, electrolyte disorders, infection, and the presence of other co-morbidities. In this study, the frequency and risk factors of AKI were investigated. Objective & Methods: This study is a cross-sectional-analytical study with a sample size of 180 people. The studied population wer...

Contrast media (CM), intravascularly administered in radiodiagnostics to enhance vascular visibility, have as complication the occurrence of acute kidney injury, beginning soon after their administration...

BACKGROUND Acute kidney injury due to glomerular bleeding has been described with IgA nephropathy and supratherapeutic warfarin anticoagulation. There is usually demonstrable tubular obstruction by erythrocyte casts associated with acute tubular injury. Although severe thrombocytopaenia increases the risk of bleeding, most cases of haematuria have been ascribed to non-glomerular or urological b...

Acute kidney injury induced by ischemia/reperfusion (IR) is a frequent complication in hospitalized patients. Mineralocorticoid receptor antagonism has shown to be helpful against renal IR consequences; however, the potential benefit of novel nonsteroidal mineralocorticoid receptor antagonists such as finerenone has to be further explored. In this study, we evaluated the efficacy of finerenone ...

 Wasp sting is a relatively common arthropod assault. This usually results in pain and mild allergic reactions, but sometimes may cause severe systemic reaction and multiorgan dysfunction including rhabdomyolysis, hemolysis, coagulopathy, hepatic, renal and cardiac complications. Along with several other pathomechanisms, rhabdomyolysis is a distinguished cause of acute kidney injury (AKI) in pa...

Background: Acute kidney injury is common in patients with sepsis and contributes to poor prognosis mortality. Early identification of high-risk can provide evidence for clinical decision-making.

BACKGROUND Case reports indicate that the use of fluoroquinolones may lead to acute kidney injury. We studied the association between the use of oral fluoroquinolones and acute kidney injury, and we examined interaction with renin-angiotensin-system blockers. METHODS We formed a nested cohort of men aged 40-85 enrolled in the United States IMS LifeLink Health Plan Claims Database between 2001...

SARS-Cov2 infection is a highly transmissible disease associated with serious pulmonary disease. Renal involvement frequent and poor prognosis; however, mechanisms of kidney injury are not well established. We present patient severe acute injury. Kidney biopsy findings revealed pattern tubular necrosis isometric vacuolization the proximal tubule. The interstitium glomeruli were normal. Electron...