Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) caused by uncontrolled complement activation and leading to thrombocytopenia, microangiopathic hemolysis acute kidney injury. Eculizumab, humanized monoclonal antibody that inhibits the cleavage protein C5, effectively reverses laboratory evidence TMA improves function in most patients with aHUS. Heredi...

Background: Absence or deficiency in Glucose-6-phosphate dehydrogenase (G6PD) enzyme in patients with G6PD deficiency presents with a wide spectrum of symptoms. This study evaluates the clinical features of acute hemolysis in children with G6PD deficiency. Materials and Methods: Seventy G6PD deficient children younger than 18 years old were included in this cross sectional study in Dastgheib H...

background: glucose-6-phosphate dehydrogenase (g6pd) deficiency is the most common enzyme disorder in human. the aim of this study was to determine the prevalence of g6pd deficiency among children and evaluate its association with abo/rh blood groups.   method: blood samples of 3401 asymptomatic children were analyzed and compared with 317 children who were admitted to hospital because of hemol...

Clostridium perfringens (CP) gives several clinical settings, from an asymptomatic to a massive intravascular hemolysis. We report a case of fatal intravascular hemolysis due to CP septicemia having a hepatic supposed starting point in the emergency department. Like in many cases, the diagnosis was made when patient had already gone into shock and died. The CP septicemia often complicated the c...

background hemolyis of red blood cells is a serious toxic effect commonly found among patients envenomed by hemiscorpius lepturus scorpion. objectives the aim of the present study was to evlaute the efficay of the avaible polyvalent antivneom in preventing this phenomena. materials and methods using a red blood cell fragility test, the anti-hemolytic effectiveness of a new antivenom serum again...

In the Amazon, treatment for Plasmodium vivax is chloroquine plus primaquine. However, this regimen limited due to risk of acute hemolytic anemia in glucose-6-phosphate dehydrogenase deficiency. Primaquine a prodrug that requires conversion by CYP2D6 enzyme be effective against malaria. A series cases were performed at an infectious diseases reference hospital Western Brazilian Amazon. The STAN...

Shiga toxin (Stx)-producing Escherichia coli (STEC) cause hemolytic uremic syndrome (HUS). This study investigated whether Stx2 induces hemolysis and whether complement is involved in the hemolytic process. RBCs and/or RBC-derived microvesicles from patients with STEC-HUS (n = 25) were investigated for the presence of C3 and C9 by flow cytometry. Patients exhibited increased C3 deposition on RB...

Over the last decade, second and third generation cephalosporins have been the most common drugs causing hemolytic anemia (HA). Of these cases, 20% have been attributed to ceftriaxone. The clinical presentation of ceftriaxone-induced HA is usually abrupt with sudden onset of pallor, tachypnea, cardio-respiratory arrest and shock. Acute renal failure (ARF) has been reported in 41% of such cases ...

There are several obstetric, medical, and surgical disorders that share many of the clinical and laboratory findings of patients with severe preeclampsia-hemolysis, elevated liver enzymes, and low platelets syndrome. Imitators of severe preeclampsia-hemolysis, elevated liver enzymes, and low platelets syndrome are life-threatening emergencies that can develop during pregnancy or in the postpart...