The serotonin 2A receptor is one of the most abundant serotonin receptors in the human CNS and is a target for drugs designed to treat psychiatric disorders (McCorvy and Roth, 2015). Significantly, levels of serotonin 2A receptors have been shown to be altered in the CNS of subjects with schizophrenia (Dean, 2003), major depressive disorders (Arora and Meltzer, 1989; Dean et al., 2014) and suic...

Acute phase C-reactive protein (CRP), raised in obesity and inflammation, is a main binding protein for leptin. It is assumed that CRP contributes to leptin confrontation by preventing leptin from crossing the blood-brain barrier (BBB). Here we defined how CRP cooperates with the BBB and whether it deters leptin from attainment CNS targets. CRP was constant in blood, but did not permeate the BB...

Viruses invade susceptible cells through a complex mechanism before injecting their genetic material into them. This causes direct damage to the host cell, as well resulting in disease corresponding system. Echovirus type 30 (E30) is member of Enterovirus B group and has recently been reported cause central nervous system (CNS) disorders, leading viral encephalitis meningitis children. In this ...

Background: Methotrexate has an important role in treatment of acute leukemia. We measured methotrexate level in CSF and blood of children with acute lymphoblastic leukemia to determine complications and outcomes. Materials and Methods: One hundred and twenty patients (73 male, 47 female), with mean age at diagnosis of 6.1 years (11mo_15years) entered the study. Patients were divided into two...

OBJECTIVES Persistent pain and psychological sequelae are common after motor vehicle collision (MVC), but their etiology remains poorly understood. Such common sequelae include whiplash-associated disorders (WAD), fibromyalgia, and posttraumatic stress disorder (PTSD). Increasing evidence suggests that these disorders share overlapping epidemiologic and clinical features. A model is proposed in...

Neuroactive testosterone metabolites synthesized by enzymes 5α-reductase and 3α/3β-hydroxysteroid oxidoreductase are critical physiological modulators of the central nervous system (CNS) function. Indeed, as discussed in this review, they exert a variety effects on myelination, brain maturation, neurotransmission, reproductive behavior, stress responses. The expression synthesis these well leve...

Introduction: VZV is a human neurotropic alpha herpes virus, and humans are the only reservoir. Infection can involve any part of nervous system. The incidence neurological manifestations associated with 1-3 per 10,000 cases.
 clinical varicella-zoster virus (VZV) infections central system (CNS) include aseptic meningitis, encephalitis, cerebral infarction granulomatous vasculitis, myeliti...

Children with injury to the central nervous system (CNS) exhibit a variety of language disorders that have been described by members of different disciplines, in different journals, using different descriptors and taxonomies. This paper is an overview of language deficits in children with CNS injury, whether congenital or acquired after a period of normal development. It first reviews the princ...