Pain is one of the leading causes decline in quality life. When pain syndromes occur, a person may experience unpleasant sensory sensations and concomitant disorders, which can lead to aggravation sleep disturbances. According experimental studies, increased sensation with reduced duration occurs due opioid, serotonergic, noradrenergic, dopaminergic antinociceptive systems dysfunction. In clini...

OBJECTIVES Quantitative sensory testing (QST) has been used to elucidate the peripheral and central mechanisms that underlie changes in pain sensitivity associated with low back pain (LBP). However, it remains unclear to what degree peripheral and central changes contribute to the generation and maintenance of LBP. The aim of this study was to compare thermal pain sensitivity, measured using QS...

OBJECTIVES To investigate the course and prognosis of shoulder pain in the first 6 months after presentation to the general practitioner. We separately studied patients with acute, subacute and chronic shoulder pain, as duration of symptoms at presentation has been shown to be the strongest predictor of outcome. METHODS A prospective cohort study with 6 months follow-up was carried out in The...

Most patients who undergo surgery recover uneventfully and resume their normal daily activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming proportion of patients. The prevailing approach of focusing on established chronic pain implicitly assumes that information generated during the acute injury phase is not important to the subsequent development of chronic p...

This study aimed to examine whether trigeminal nerve injury induces chronic nociceptive behaviour and central sensitization (CS) in functionally identified medullary dorsal horn (MDH) nociceptive neurons in mice, and whether CS in acute and chronic orofacial pain models and nociceptive behaviour in the chronic model are affected by systemic administration of pregabalin. Infraorbital nerve injur...

Diabetic rats in long-term display an augmented nociceptive response to chemical, mechanical, and thermal stimuli. Furthermore, hyperalgesia is one of the major symptoms of diabetic neuropathy in some patients. Considering the antidiabetic potential of pepper, this study was carried out to evaluate the possible analgesic effect of pepper-mixed food intake in male streptozotocin-induced diabetic...

Diabetic rats in long-term display an augmented nociceptive response to chemical, mechanical, and thermal stimuli. Furthermore, hyperalgesia is one of the major symptoms of diabetic neuropathy in some patients. Considering the antidiabetic potential of pepper, this study was carried out to evaluate the possible analgesic effect of pepper-mixed food intake in male streptozotocin-induced diabetic...

OBJECTIVE There is limited information about the extent to which the association between preoperative and chronic postoperative pain is mediated via pain-on-movement or pain-at-rest. We explored these associations in patients undergoing total hip replacement (THR) and total knee replacement (TKR). METHODS A total of 322 and 316 patients receiving THR and TKR, respectively, were recruited into...

All chronic pain was once acute, but not all acute pain becomes chronic. The transition of acute postoperative pain to chronic post surgical pain is a complex and poorly understood developmental process. The manuscript describes the various factors associated with the transition from acute to chronic pain. The preoperative, intraoperative and postoperative surgical, psychosocial, socio-environm...