When rhesus monkeys with acute Plasmodium knowlesi infection recover after administration of quinine, complement-fixing antibodies are present at maximum titer in the serum soon after the first acute infection has subsided (1), and protective (2) and agglutinating (3) antibodies are demonstrable somewhat later in the course of the chronic disease. Relapses cause an increase in the titer of comp...

Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab')2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication. Similar ricin-binding affinities and neutralizing activities in vitro were observed between IgG and F(ab')2 when compared at the same molar conc...

The transfer of maternal immune factors to the newborn is critical for protection from infectious disease in early life. Maternally acquired passive immunity provides protection until the infant is beyond early life's increased susceptibility to severe infections or until active immunity is achieved following infant's primary immunization. However, as reviewed here, human immunodeficiency virus...

The similarity or difference in the character of the individuality-, raceand species-diff erentials between host and transplant determines the reaction of the host against the transplant in the case of normal tissues as well as of tumors and in addition it determines the active immunity against tumor growth. In my earlier publications, I have compared this series of differentials and reactions ...

The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the produc...

Human tumors are immunogenic and tumor-associated proteins that generate immunity in cancer patients have been defined. Many of these proteins are involved in the malignant transformation and play a role in either initiating or maintaining the malignant phenotype. Furthermore, due to technical advances in basic immunology over the last decade we have a better understanding of the immune effecto...

Injection into rhesus monkeys of Plasmodium knowlesi killed by heat, formalin, drying, or freezing and thawing stimulates the production of complement-fixing antibodies, but no demonstrable agglutinating or protective antibodies are formed. Possible differences in the immunity mechanisms concerned in active infection and in artificial immunization are discussed.

1. Experiments are reported on the use of poliomyelitis virus neutralized by specific antiserum as an agent to induce active immunity against the experimental disease in monkeys. 2. The results indicate that protection can be conferred upon a certain number of the treated animals. 3. The neutralized material gave rise in no instance to symptoms of disease in the treated monkeys. 4. Active polio...

Outer membrane protein antigens usually have strong immunogenicities, closely interact with the immune system and play a significant role in the development of new vaccines. The outer membrane proteins of Salmonella paratyphi A (S. paratyphi A) were screened for immunogenicity and immunoprotection for potential vaccine targets. In this study, the ...

1. The protective substances contained in specific precipitates from antipneumococcus serum can be extracted by suitable chemical and physical agents, dilute sodium carbonate at 42 degrees C. being especially advantageous as an extractive agent. 2. The resulting water-clear extracts, when made up to the original volume of the serum used for precipitation, protect animals almost as well as does ...