Ziel/Aim Restoration of iodine incorporation (redifferentiation) was achieved in previously radioiodine-refractory, unresectable thyroid carcinoma by mitogen-activated protein kinase (MAPK) inhibition. However, redifferentiation unsatisfactory BRAFV600E mutated (BRAF-MUT) thus far. Here we assess safety and efficacy therapy through genotype-guided MAPK-modulation patients with BRAF-MUT or wild ...

Accumulation of gene changes and chromosomal instability in response to cellular DNA damage lead to cancer. DNA damage induces cell cycle checkpoints pathways. Checkpoints regulate DNA replication and cell cycle progression, chromatin restructuring, and apoptosis. Checkpoint kinase 2 (chk2) is activated in response to DNA lesions. ATM phosphorylate chk2. The activated Chk2 kinase can phosphoryl...

Introduction: Obesity is a metabolic disease with an increase both in cell size (hypertrophy) and number (hyperplasia) following differentiation of new adipocytes. Adipogenesis well-orchestrated program which mitotic clonal expansion (MCE) occurs the early step followed by late terminal one. Methods: Aim study was to evaluate vitro effects cyanidin-3-O-glucoside (C3G), anthocyanin present many ...