protection of a sound environment is one of the most contravertioal issues of the legal and political world, and different letters are provided in this regard. but in respect of how to implement the aim of promoting and protecting the environment, the governments have utilized different legal instruments; the last of which is the concept of liability for environmental damages. level in which di...

increasing rate of world population growth has tremendous and of ten detrimental impacts on natural environment of our planet. unreasonable consumption of non-renewable sources of energy, deforestation, and the extinction of species are among these impacts. there are many who believe that global warming which is resulted due to population :growth, urbanization and over and irresponsible consump...

despite several authors having studied the strategic approach to environmental orientation and,considering that environmental proactivity is emerging in business strategy, it still remains unclear which realactions influence a firm’s environmental orientation. an empirical analysis of a sample of 126 spanish companies shows that firms’ actions are explained as training, information and divulgat...

Over the last several decades, dioxins have become the subject of intense public and scientific scrutiny. This is the result of not only their widespread presence in the environment but also their great toxicity. The environmental issue has been addressed through the study of the production, release and fate of dioxins and related substances, as well as the development of analytical techniques ...

Pyrimido[5,4-c]cinnoline and pyrimido[5,4-c]quinoline derivatives have been tested as potential intercalators. All of them embody stuctural properties alike to afford intercalating activity. Their cytotoxicity was determined on the two human leukemia cell lines, the promyelocytic HL-60 and the lymphoblastic NALM-6. The viability of cells exposed continuously to tested compounds was estimated by...

The purpose of this paper is to present some of the more carefully studied aspects of the preclinical toxicology of antineo-plastic agents, and apply these findings (with certain obvious cautions) to the area of environmental toxicology. Most of the studies to be described here are the result of applied toxicologic studies performed in support of the clinical introduction of new chemicals in th...

This chapter provides a review and evaluation of the literature pertinent to joint toxic action of the mixture and its components. The text is generally organized so that human data are presented first, and studies are grouped by route, and by endpoint where that is feasible. In Section 2.2, summary tables are provided at the end of each section on the binary mixtures. The tables are designed t...

Aβ immunotherapy brought us not only hope for but also led to greater attention to the mechanism underlying the clearance of amyloid β (Aβ), which provided fascinating insights into disease-relevant molecules such as toxic Aβ oligomers (AβOs). Accumulated lines of evidence indicate that AβOs play a causative role in the pathogenesis of Alzheimer’s disease (AD), leading to a synaptic failure, wh...

Retinol (vitamin A) in concentrations above (5 microgram/ml inhibits the stimulation of human lymphocytes by phytohemagglutinin and phorbol myristate acetate. This is in contrast to bovine lymphocytes in which retinol inhibits only phorbol myristate acetate stimulation of lymphocytes. The cause of the inhibition does not appear to be due to a direct toxic action because the viability and ultras...

Pattern users are faced with difficulties in understanding when and how to use the increasing number of available design patterns. This is mainly due to the inherent ambiguity in the existing means (textual and graphical) of describing them. Hence, there is a need to introduce formalism in order to describe them accurately and allow rigorous reasoning about them. The main problem of existing fo...