نتایج جستجو برای: acridine
تعداد نتایج: 3073 فیلتر نتایج به سال:
In the crystal structure of the title compound, C(14)H(12)NS(+)·CF(3)SO(3) (-), N-H⋯O hydrogen bonds link cations and anions into ion pairs. Inversely oriented ion pairs form stacks through multidirectional π-π inter-actions among the acridine units. The crystal structure features a network of C-H⋯O inter-actions among stacks and also long-range electrostatic inter-actions among ions. In the pa...
Purpose: To image leukocyte adherence to the vascular endothelium and extravasation into surrounding tissues in neovascularized corneas using acridine orange, a selective DNA stain, in rats Methods: Corneal neovascularization was induced by placing two sutures in the cornea of one eye of 12 Long-Evans rats. One week later, acridine orange (4 mg/kg) was injected via the tail vein and the eyes we...
BACKGROUND Trichomonas vaginalis is a parasitic protozoan which causes most common non viral sexually transmitted disease trichomoniasis. Direct microscopic examination of vaginal fluid remains the most widely used diagnostic test. Although, wet mount examination is the most cost-effective diagnostic test, but it has low sensitivity resulting in under diagnosis of the disease. Therefore, to ove...
Semisynthetic aminoglycoside derivatives may provide a means to selectively target viral RNA sites, including the HIV-1 Rev response element (RRE). The design, synthesis, and evaluation of derivatives based upon neomycin B, kanamycin A, and tobramycin conjugates of 9-aminoacridine are presented. To evaluate the importance of the acridine moiety, a series of dimeric aminoglycosides as well as un...
We have explored a series of trisubstituted acridine-peptide conjugates for their ability to recognize and discriminate between DNA quadruplexes derived from the human telomere, and the c-kit and N-ras proto-oncogenes. Quadruplex affinity was measured as the peptide sequences were varied, together with their substitution position on the acridine, and the identity of the C-terminus (acid or amid...
3-nitro-9-[2-(dialkylamino)ethyl)]aminoacridines (alkyl = methyl or ethyl) have been used as ligands towards platinum(If). The end product is a complex in which the acridine acts as a tridentate ligand contributing the two exocyclic nitrogen atoms and one of the two peri carbons. The metallation takes place predominantly at the peri position of the unsubstituted ring. The coordinated acridine i...
Benz[a]acridine was considered by previous IARC Working Groups in 1983 and 1987 (IARC, 1983, 1987). Since that time, new data have become available; these have been incorporated into the Monograph, and taken into consideration in the present evaluation. Benz[c]acridine was considered by previous Working Groups in 1972, 1983, and 1987 (IARC, 1973a, 1983, 1987). Since that time, new data have bec...
Parasitic diseases are of enormous public health significance in developing countries-a situation compounded by the toxicity of and resistance to many current chemotherapeutics. We investigated a focused library of 18 structurally diverse bis-acridine compounds for in vitro bioactivity against seven protozoan and one helminth parasite species and compared the bioactivities and the cytotoxicitie...
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